1. A patient comes to you complaining that whenever he takes aspirin for headache, he develops severe shortness of breath. Which of t the following may be partly responsible for this Thromboxane A2 Prostaglandin E Leukotrienes Prostacyclin 2. Which of the following can be safely given in a kidney patient Fluconazole Acetyl salicylic acid Ibuprofen Ketorolac 3. Comparison of efficacy of a new drug B with an existing drug A is done in which phase of clinical trials Phase I Phase II Phase III Phase IV 4. Cyclooxygenase enzyme is not inhibited by Phenylbutazone Diclofenac Warfarin Aspirin 5. Which of these is a selective COX-2 inhibitor: Celecoxib Aspirin Ketorolac lndomethacin 6. Which of the following drug inhibits cell wall synthesis Erythromycin Cephalosporin Doxycycline Aminoglycosides 7. The plasma half life of aspirin is longer for anti-inflammatory doses compared to that for analgesic dose is independent of dose can be increased by alkalinizing the urine is shorter for anti-inflammatory doses compared to that for analgesic dose 8. Second generation fluoroquinolones: Ciprofloxacin Pefloxacin Norfloxacin Levofloxacin 9. Use of aspirin in children with viral disease is associated with Metabolic acidosis Fixed drug eruption Renal tubular acidosis Reye’s syndrome 10. One of the following is not penicillinase susceptible Piperacillin Amoxicillin Cloxacillin Penicillin G 11. Drug of choice of malignant hyperthermia Dantrolene potassium Succinylcholine Diazepam Dantrolene sodium 12. Which NSAID undergoes enterohepatic circulation Phenylbutazone Piroxicam Ibuprofen Aspirin 13. Drug resistance in the mycobacterium tuberculosis to isoniazid is seen due to which of the following: Conjugation Transformation Transduction Mutation 14. A highly ionised drug Crosses the placental barrier easily Is well absorbed from intestine Is highly protein bound Is excreted mainly by kidneys 15. One of the following is not an antifungal agent Clofazimine Ketoconazole Undecyclenic acid Ciplopirox 16. Rofecoxib was withdrawn due to liver adenoma Ischemic heart disease Gastric ulcer Renal complication 17. Which of the following antibiotic is used in the treatment of clostridium difficile associated diarrhea Clindamycin Piperacillin Metronidazole Ciprofloxacin 18. Every antibiotic has a mean inhibitory concentration (MIC) for an organism. A drug should be given how many times its mean inhibitory concentration for effective control of infections(prophylaxis) in the head and neck area 2 4 3 1 19. Local anaesthetic used as an antiarrhythmic agent is Bupivacaine Chlorprocaine Cocaine lignocaine 20. Therapeutic index is a measure of Bioavailability Efficacy Drug safety potency Loading … Question 1 of 20
