Pharmacology #8 – Unidontia

1. Xenon anaesthesia all are true except

Non explosive

Low blood solubility

Slow induction and recovery

Minimal cardiovascular side effects

2. The plasma half life of aspirin

can be increased by alkalinizing the urine

is independent of dose

is longer for anti-inflammatory doses compared to that for analgesic dose

is shorter for anti-inflammatory doses compared to that for analgesic dose

3. A 20 year old female weighing 55 kg is admitted to the emergency department having consumed 10 g of paracetamol together with alohol 6 hours earlier. A serum paracetamol level is reported as 400 micrograms/ml. Which of the following is correct with respect to this

Hepatotoxicity is likely to occur

Gastric lavage is mandatory

Abnormalities of the kidney function are likely to be present

Administration of activated charcoal

4. Which of the following anti inflammatory drug is a COX 2 inhibitor

Aspirin

Rofecoxib

Ketoprofen

Sulindac

5. True regarding selective COX-2 inhibitors compared to nonselective NSAIDS is:

Does not have anti-pyretic effect

Thromboembolism incidence is decreased

Higher incidence of GI bleed

Equivalent renal toxicity

6. Drug not used in H.pyroli infection

amoxicillin

Mosapride

Metronidazole

Omeprazole

7. Therapeutic drug monitoring is required in all except

Tacrolimus

Phenytoin

Metformin

Cyclosporin

8. Drug of choice for syphillis in a preganant lady is

tetracycline

Penicillin

Azithromycin

ceftriaxone

9. Auditory toxicity is maximum with

Amikacin

Kanamycin

Streptomycin

Tobramycin

10. Which drug would treat both dermatophysis and candida infections

Nystatin

Ketoconazole

Tolnaftate

Griseofulvin

11. 25 years old asthmatic patient on theophyllline is given ciprofloxacin by dentist. He developed dyspnoea and palpitation. What could be the cause

ciprofloxacin displaces receptor binding of theophylline

ciprofloxacin inhibits metabolism of theophylline

ciprofloxacin reduces plasma protein binding of theophylline

ciprofloxacin increases metabolism of theophylline

12. Which of the following antibiotic is used in the treatment of clostridium difficile associated diarrhea

Ciprofloxacin

Piperacillin

Metronidazole

Clindamycin

13. In leprosy, the best bactericidal agent is

Clofazimine

Rifampicin

Dapsone

Ethionamide

14. True about orphan drug is

Developed for orphans

Rare drug for common disease

Drugs used very rarely

Drugs used for rare diseases

15. Immediate toxic reactions to local anesthetic administration are most commonly due to

hypersensitivity to the anesthetic agent.

hypersensitivity to the vasoconstrictor.

deterioration of the anesthetic agent.

excessive blood level of the anesthetic agent.

16. Comparison of efficacy of a new drug B with an existing drug A is done in which phase of clinical trials

Phase I

Phase III

Phase II

Phase IV

17. Which of these is a selective COX-2 inhibitor:

lndomethacin

Ketorolac

Celecoxib

Aspirin

18. Which can be given safely in renal failure

Doxycycline

Gentamicin

Amphoterecin B

Tetracycline

19. When 2 drugs A and B are compared false statement is

If 1 mg of drug A has higher degree of same effect than 1 mg of drug B then A is more efficacious than B

If drug A produces more effect than maximum tolerable dose of drug B then A is more efficacious than B

Dose and drug efficacy are not related

If 1 mg of drug A produces same effect as 3 mg of drug B then A is more potent than B

20. The antidote of choice in paracetamol poisoning is

Methylene blue

Sodium bicarbonate

Flumazenil

N-acetylcysteine

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