1. Angiotensin II causes all except Stimulates aldosterone release Stimulates release of ADH Vasodilation Increases thirst 2. Multiple drug resistance is transferred through transduction mutation conjugation Transformation 3. In which of the following phases of clinical trial of drug ethical clearance is not required Phase II Phase IV Phase III Phase I 4. Which of these is a selective COX-2 inhibitor: Celecoxib Ketorolac Aspirin lndomethacin 5. When comparing opioids with NSAIDS which of the following is correct? NSAIDS cause more constipation. Opioids impair gastric motility to a greater extent. NSAIDS cause more drowsiness Opioids predispose to more bleeding. 6. Second gas effect is exerted by which of the following gas when coadministered with halothane Nitrous oxide Nitrogen Helium Cyclopropane 7. The plasma half life of aspirin is independent of dose is shorter for anti-inflammatory doses compared to that for analgesic dose can be increased by alkalinizing the urine is longer for anti-inflammatory doses compared to that for analgesic dose 8. Antifungal used as cancer therapeutic agent is Flucytosine Terbinafine Nystatin Voriconazole 9. In spinal anaesthesia the drug is deposited between Dura and vertebra Dura and arachnoid Pia and arachnoid Into the cord substance 10. Which anti tubercular causes reversible Red Orange Urine: Ethambutol Pyrazinamide Isoniazid Rifampicin 11. Which of the following drugs has spasmolytic activity and could also be used in the management of seizure casued by overdose of a local anaesthetic Dantrolene Baclofen Tizanidine Diazepam 12. Which drug would treat both dermatophysis and candida infections Ketoconazole Nystatin Griseofulvin Tolnaftate 13. Co prescription of amoxicillin with clavulanic acid is an example of Synergism Displacement Antagonism Cumulative action 14. Which of the following is not a phase 1 reaction in drug metabolism Hydrolysis Oxidation Reduction Conjugation 15. Mechanism of action of chloramphenicol is cell wall synthesis inhibitor Glycopeptidase inhibitor 50s ribosome inhibitor 30 s ribosome inhibitor 16. What is NOT true for selective COX-2 inhibitor is safe in patients with renal insufficiency They donot offer the cardio protective effect fewer incidence of gastrointestinal side effect The analgesic and anti-inflammtory effects identical to that of non selective NSAID 17. Mechanism of action of aspirin in MI is Thrombolytic action Decreased serum lipids Inhibition of Cyclooxygenase Inhibition of thromboxane synthesis 18. Long-term use of aspirin in rheumatoid arthritis is limited by its propensity to cause Salicylism Metabolic acidosis Gastric mucosal damage Hypersensitivity reactions 19. Efficacy of a drug refers to Affinity of drug that binds to receptors and activates it Dose that is required to produce response Maximum response a drug can produce Affinity of drug to bind the receptors 20. Zero order kinetics is shown by all except High dose salicyclates Phenytoin Ethanol Methotrexate Loading … Question 1 of 20
