1. In leprosy, the best bactericidal agent is Dapsone Rifampicin Clofazimine Ethionamide 2. Therapeutic uses of prostaglandin E1 include all of the following except Primary pulmonary hypertension Medical termination of pregnancy Maintenance of patent ductus arteriosus Impotence 3. 40 year old patient was taking warfarin 4 gms for DVT prophylaxis. She was given ceftriaxone 8 hrs iv for dental infection. Later the lady experienced episode of vaginal bleeding and darkening of urine. What is the cause? ceftriaxone inhibits metabolism of warfarin Gut flora was inhibited by ceftriaxone ceftriaxone is an enzyme inducer Both have additional trombocytopenic effect 4. Shortest acting opioid is Remifentanyl Morphine Sufentanyl Fentanyl 5. Which of the following is a first generation cephalosporin Cefepime Cefadroxil Cefoperazone Cefotaxime 6. Which of the following action is ascribed to Delta type of opiod receptors Euphoria Respiratory depression Reduced intestinal motility Supraspinal analgesia 7. A lady taking warfarin ,which drug is contraindicated Fluconazole Amphotericin B Terfenadine Nystatin 8. In steady state model of metabolism A->B->C->D, which of the following is true Concentration of B and C is increased Concentration of B and C is decreased because rate of formation is decreased Concentration of both B and C is constant because rate of formation is equal to rate of utilisation Concentration of B is increased while that of C is decreased 9. Drug which can used in management of streptococcal endocarditis susceptible to penicillin, but patient developing immediate allergy following penicillin administration, is Meropenem Carbenicillin Ceftriaxone Vancomycin 10. The persistent suppression of bacterial growth that may occur after limited exposure to some antimicrobial drug is called Time dependent killing Concentration dependent killing Post antibiotic effect Sequential blockade 11. A non-competitive inhibitor of an enzyme Increases Vmax Increases Km with no or little change in Vmax Decreases Vmax Decreases Km 12. Fluconazole resistant candidiasis in a HIV positive patient is treated by Ketoconazole Nystatin Amphotericin B Clotrimazole 13. A highly ionised drug Is highly protein bound Crosses the placental barrier easily Is well absorbed from intestine Is excreted mainly by kidneys 14. The therapeutic advantage that penicillin V has over penicillin G is Broader antibacterial spectrum Greater resistance to penicillinase Slower renal excretion More reliable oral absorption 15. Sulphonamides act by Non competitive inhibition Competitive inhibition Allosteric inhibition None of these 16. Safest 1st line ATT in renal failure is Isoniazid Streptomycin Ethambutol Rifampicin 17. The most potent and longest acting anaesthetic agent is Bupivacaine Tetracaine Lignocaine Dibucaine 18. Second generation fluoroquinolones: Levofloxacin Norfloxacin Ciprofloxacin Pefloxacin 19. Statins are used for cholesterol reduction, It antagonises HMG COA reductase. What kind of inhibition is seen Competitive Non competitive Non specific Functional 20. Cardiac arrythmias are most commonly seen during administration of Ether Thiopental Nitrous oxide Halothane Loading … Question 1 of 20
