1. Which of the following statements is not true about NSAIDS duration of action of aspirin is primarily related to the pharmacokinetic clearance of the drug from the body Acetyl salicylic acid is an irreversible inhibitor of COX enzyme Salicylic acid reduces in vivo synthesis of prostaglandins Antiplatelet effect of low dose aspirin is related to pre systemic COX inhibition 2. Pharmacovigilance means Monitoring pharma students Monitoring of drug safety Monitoring of unethical trade of drugs Monitoring drug efficacy 3. Which NSAID undergoes enterohepatic circulation Piroxicam Phenylbutazone Ibuprofen Aspirin 4. Clinically significant drug interaction occurs between pyridoxime and all of the following drugs except Hydralazine Levodopa Isoniazid Cyclosporine 5. What is true about Tramadol: Increased sensitivity for Mu receptors Causes less respiratory depression than Morphine Facilitates reuptake of Noradrenaline It is an NSAID 6. Along with INH which vitamin is given Pyridoxine Niacin Cyanocobalamin Riboflavin 7. Use of aspirin in children with viral disease is associated with Metabolic acidosis Fixed drug eruption Reye’s syndrome Renal tubular acidosis 8. Malignant hyperthermia is a rare complication of the use of the following anesthetic Halothane Thiopentone sodium Ether Ketamine 9. In leprosy, the best bactericidal agent is Clofazimine Rifampicin Ethionamide Dapsone 10. 40 year old patient was taking warfarin 4 gms for DVT prophylaxis. She was given ceftriaxone 8 hrs iv for dental infection. Later the lady experienced episode of vaginal bleeding and darkening of urine. What is the cause? Both have additional trombocytopenic effect ceftriaxone inhibits metabolism of warfarin ceftriaxone is an enzyme inducer Gut flora was inhibited by ceftriaxone 11. The following causes increased intraocular pressure Thiopentone Althesin Barbiturate Ketamine 12. General anesthetics can do all of the following EXCEPT stimulate medullary centers. reduce perception of painful stimuli. produce a state of unconsciousness. produce delirium. 13. Immediate toxic reactions to local anesthetic administration are most commonly due to deterioration of the anesthetic agent. hypersensitivity to the vasoconstrictor. hypersensitivity to the anesthetic agent. excessive blood level of the anesthetic agent. 14. Mechanism of action of aspirin in MI is Decreased serum lipids Inhibition of Cyclooxygenase Thrombolytic action Inhibition of thromboxane synthesis 15. Which drug causes least hepatic failure: Streptomycin INH Pyrazinamide Rifampicin 16. Which of the following drugs is most likely to be effective against multi-drug resistant strains of M.tuberculosis ,including those resistant to streptomycin Amikacin Gentamicin Spectinomycin Clarithromycin 17. Which of the following acts by inhibiting cell wall synthesis: Nalidixic acid Ciprofloxacin Penicillin Erythromycin 18. When comparing opioids with NSAIDS which of the following is correct? NSAIDS cause more constipation. NSAIDS cause more drowsiness Opioids impair gastric motility to a greater extent. Opioids predispose to more bleeding. 19. True statement regarding development of drug resistance in MRSA is Occurs due to change in penicillin binding proteins Chromosome mediated Treated with amoxicillin + clavulanic acid Results due to penicillinase enzyme production 20. A patient on aspirin will have increase in Bleeding time Prothrombin time Activated partial thromboplastin time Clotting time Loading … Question 1 of 20
