1. Function of myenteric plexus is to regulate Local blood flow Motility All of the above GI secretion 2. If a person is having ventricular tachycardia,extra systoles appears in P wave QRS complex T wave R wave 3. Eosinophils are characteristically seen in which of the following conditions? Parasitic infestations Fungal infections Bacterial infections Viral infections 4. A child on administration of Penicillin developed fever, rashes, urticaria and swelling. It is due to: Ig G mediated hypersensitivity Delayed hypersensivity Ig E mediated hypersensitivity Immune complex cytotoxicity 5. Most common cause of nephrotic syndrome in adults: Focal segmental glomerulonephritis Membrano-proliferative glomerulonephritis Minimal change disease Diffuse glomerulonephritis 6. basal metabolic rate depends most closely on body surface area obesity body mass index lean body mass 7. Gram -ve bacteria stain during gram staining: Red color Blue color Colorless Green 8. Two particles have same diameter. The one which will pass easily through glomerular membrane has Any of the above Positive charge negative charge Charge has no relation 9. Which of the following enzyme is required to induce the formation of a plasma clot by pathogenic staphylococci Coagulase Fibrinolystin Lysozymet S-protein 10. You have to draw blood from a patient. When will you give EDTA? EDTA will be added in test tube EDTA is not an anticoagulant Orally starting several days before Through I.V. route before drawing blood 11. Blood agar is Simple media Transport media Differential media Enriched media 12. why fetal cells continue to divide but terminally differentiated adult cells do not divide there are many cyclin inhibitors which prevent cell from entering into S phase in adults phosphatase is absent in fetal cells proteinase is absent in fetus absence of CD kinase 13. Phage conversion is required for: All of the above Diphtheria Gonorrhoea Tularemia 14. Earliest marker of renal damage in a known case of diabetes mellitus is: Microalbuminuria Glycosuria Increase serum urea Increase serum creatinine 15. Ulthoff sign is seen in: Multiple sclerosis Cerebral palsy Parkinsonism Alzheimer’s disease 16. All of the following statements about staphylococcus aureus are true except Most common source of infection is cross infection from infected people Methicillin resistance is chromosomally mediated bout 30% of general population is healthy nasal carriers Epidermolysin and TSS toxin are superantigen 17. Platelet aggregation and vasoconstriction caused by: PGI2 Thromboxane A2 Leukotriene B4 PGD2 18. Decreased basal metabolic rate is seen in: Obesity Feeding Exercise Hyperthyrodism 19. All of the following are characteristic of an exudate, except: Protein-rich Cell-rich Low specific gravity Glucose-poor 20. Antibiotic sensitivity and resistance of microorganisms is determined by DNA probe Direct microscopy ELISA Culture 21. prion – true is sensitive to most chemical sterilization evokes strong immunologic reaction contains DNA/RNA have long incubation period 22. Fluid of choice in infant diarrhoea Sugar water Dextrose ORS Salt water 23. Actinomycetes is Fungus Gram negative bacteria ram positive bacteria A yeast like form 24. in a normal person which of the following occurs when he becomes supine from a standing position heart rate increases and settles to a higher level there is an immediate increase in venous return decreased perfusion at the apex of lung cerebral blood flow increases 25. A 60 years old patient having cardiorespiratory arrest in hospital ward, for oxygenation what should be done immediately? Cricothyroid membrane puncture Nasal intubation Oral intubation Tracheostomy 26. IL-1 helps in: Inhibition of B-lymphocytes Inhibits the chemotaxis of neutrophils and macrophages Stimulation of T-lymphocytes Decreases fibroblast and bone resorption activity 27. Which of the following is not seen in secondary adrenal insufficiency Hypoglycemia Lassitude Postural hypertension Pigmentation 28. Most important step in management of acute diarrhea: Antibiotic therapy Fluid replacement Give antimotility drugs like loperamide Give motility reducing agents like bismuth 29. Granuloma is characterized by all of the following except: A reaction of acute inflammation Accumulation of modified macrophages A specific type of chronic inflammation Initiated by a number of infectious and non infectious agents 30. Cytokines are soluble proteins secreted by which of the following cells? All of the above Macrophages Fibroblasts Lymphocytes 31. All of the following are formed via the cyclooxygenase pathway, except: Prostacyclin Leukotrienes Thromboxanes Prostaglandins 32. Not a characteristic of white infarct: It can be transiently red Seen in soft tissue Involves wedge shaped area with apex pointing towards arterial obstruction Occurs due to arterial obstruction 33. False about Staphylococcus lugdunensis Skin commensal Does not produce coagulase Susceptible to antimicrobial Causes infection of native valve 34. Causative organism for native valve infective endocarditis: Gram negative organisms E. CoIi Hemophilus Staph aureus 35. maximum phosphate is reabsorbed in Loop of henle DCT Collecting duct PCT 36. Multiple drug resistance of bacteria depends on which of the following: Fertility factor (F +) All of above Resistance transfer factor (RTF) Colicigenic factor (Col) 37. H. pylori infection is seen in all except: Fundal gastritis Duodenal ulcer Gastric lymphoma Gastric carcinoma 38. The oxygen hemoglobin dissociation curve is sigmoid because Oxygen affinity of haemoglobin decreases when the pH of blood falls Binding of one oxygen molecule decrease the affinity of binding other O2 molecules Binding of oxygen to hemoglobin reduces the affinity of Hb for CO2 Binding of one oxygen molecule increases the affinity of binding other O2 molecules 39. Peripheral nerve regenerates at the rate of mm per day 1 2 5 0.5 40. Which of the following coagulation factors causes cross linking and stabilisation of clot factor XIII Thrombin Factor IX Factor VIII 41. Continuous murmur is seen in all of the following conditions except PDA Pulmonary AV fistula Coronary AV fistula VSD with aortic regurgitation 42. complement factor used to identify activation through common pathway is C5 factor B C3 C4 43. Best test for mycoplasma infection is CXR PCR of respiratory secretions Culture of transtracheal aspirate gram stain of transtracheal aspirate 44. Kolmer test is a screening test done for Syphilis Tuberculosis Gonorrhea Lymphoma 45. An increase in the size of an organ or tissue due to an increase in the size of cells is known as: Aplasia Hypertrophy Hyperplasia Atrophy 46. Which of the following situations will lead to increased viscosity of blood Fasting state multiple myeloma Hypoglycemia amyloidogenesis 47. The mechanism of genetic transfer where a phage serves as a vehicle Is Transformation Lysogeny Conjugation Translation 48. All are true about Leptospirosis except: Penicillin G is drug of choice Latent period is 10 days IgM is formed in 5 days Urine and faeces are main mode of transmission 49. normal anion gap is (in mEq/l) 3 to 5 10 to 12 25 to 30 18 to 20 50. The most important parameter to monitor Dengue haemorrhagic fever is Total leucocyte count Haemoglobin Haematocrit Platelet count 51. All of the following vascular changes are observed in acute inflammation, except – Stasis of blood. Decreased hydrostatic pressure. Increased vascular permeability. Vasodilation. 52. Most common structure compressed by aneurysm of posterior communicating artery in the circle of Willis hypophysis cerebri oculomotor nerve trochlear nerve optic nerve 53. Bacteria used in probiotics is E. Coli Bifidobacterium All Diphtheria 54. Drug of choice in neonatal seizures Pentobarbital Topiramate Phenytoin Phenobarbitone 55. Which one of the following clinical findings excludes the diagnosis of polymyositis Neck muscle involvement Abdominal muscle involvement Dysphagia Extraocular muscle involvement 56. All of the following infections may be transmitted by dental instruments except Hepatitis C HIV Hepatitis E Hepatitis B 57. The following immunoglobulin is not known to fix complement IgG IgM IgA IgE 58. Anaphylotoxins: Cause enhanced capillary permeability Induce smooth muscle contraction All of the above Produce inflammation 59. Potential developed due to movement of freely diffusible ions across a semi permeable membrane is calculated using Goldman-Hodgkin-Katz equation Fick principle Gibbs equation Nernst equation 60. Not essential for brain death loss of pupillary reflex loss of brain stem function Negative apnea test loss of deep tendon reflex 61. The following is true about malaria Plasmodium vivax can be detected by HRP-2 dipstick Plasmodium vivax causes enlargement of affected RBC Plasmodium falciparum can cause relapse LDH card test quantitates the falciparum parasitaemia 62. Half-Life of free HIV in plasma is: 6 hours 3 months 24 hours 12 hours 63. Best method of sterilizing disposable syringes: UV rays Gamma rays Hot air oven Boiling 64. APGAR score is a quantitative method of assessing score of new born status based on Neurologic,digestive and respiratory Neurologic ,circulatory and respiratory Neurologic,circulatory and renal Neurologic,renal and respiratory 65. Which of the following would shift the oxygen-hemoglobin dissociation curve to the right? Decreased pH Decreased temperature Decreased PCO2 Carbon monoxide poisoning 66. A decrease in which of the following parameters would tend to increase the glomerular capillary hydrostatic pressure? Efferent arteriolar resistance Bowman’s capsular hydrostatic pressure Afferent arteriolar resistance Capillary filtration coefficient 67. Malignant tumour that shows periosteal reaction: Ewing’s sarcoma Osteoclastoma Osteosarcoma Garre’s osteomyelitis 68. Vagal stimulation of the heart causes decrease in heart rate by Decrease in action potential spike Increase in repolarisation Decrease in slope of prepotential Decrease conduction 69. Immunoglobulin crossing placenta is IgM IgD IgA IgG 70. In body plethysmography,a person is asked to expire against a closed glottis. What will be the change in the pressure in the lung and the box Decrease in both Decrease in lung, increase in box Increase in both Increase in lung, decrease in box 71. Malignant epithelial cells have an increased number and wider distribution of which of the following receptors Complement Laminin Histamine IL-1 72. The host tissue response in acute inflammation is all except Exudative Granulomatous Cytopathic Necrotizing 73. iron in hemoglobin is in complex form free form ferrous form ferric form 74. Consider two patients with atherosclerosis, one is diabetic and other is non-diabetic. When compare to non-diabetic, diabetic patient has hundred times increased risk of Lower limb ischemia Myocardial infarction Stroke vertebro basilar insufficiency 75. rods and cones differ in all except acuity signal transduction wavelength light sensitivity 76. Which of the following is not true about from a transfusion related acute lung injury Resolves in 2-3 weeks Supportive care is mainstay of treatment No role of steroids High mortality rate of 10 percent 77. Streptococcus mutans can be distinguished from other streptococci by Production of extracellular polysaccharides Hemolysis on blood agar Fermentation of mannitol and sorbitol Optochin sensitivity 78. Under normal conditions, the main drive for respiration is the arterial pH acting through peripheral chemoreceptors arterial PCO2 acting through central chemoreceptors arterial PCO2 acting through peripheral chemoreceptors arterial pH acting through central chemoreceptors 79. Which of the following conditions is least likely to present as an eccentric osteolytic lesion? Giant cell tumor Simple bone cyst Fibrous cortical defect Aneurismal bone cyst 80. In which of the following disease maternal antibodies are not protective to the child Pertusis measles Rubella Chicken pox 81. NK CELL acts on viruses because Expression of MHC I on cell surface receptor Expression of MHC II on cell surface receptor Non Expression of MHC I on cell surface receptor NON Expression of MHC II on cell surface receptor 82. Urea breath test used for: Kidney Stomach Lung Liver 83. Tumor lysis syndrome is characterized by all except: Hypercalcemia Hyperkalemia Hyperuricemia Hyperphosphatemia 84. Sunlight has sterilizing effect because: Heat is present It has short wavelength It has long wavelength Ozone is present in the environment 85. Which valve is most affected by rheumatic fever Tricuspid valve Pulmonary valve Aortic valve Mitral valve 86. Which of the following is likely to be decreased in a patient with severe anemia (Hb less than 7 g/dL)? Arterial O2 saturation Cardiac output Arterial O2 content Arterial PO2 87. If a creatinine clearance of 100 mL/min changes to 50 mL/min over 1 year, assuming that there has been no change in diet, which of the following physiologic changes can be expected? 2-fold decrease in blood urea nitrogen concentration A 2-fold increase in creatinine excretion rate A 2-fold decrease in creatinine excretion rate A 2-fold increase in plasma creatinine concentration 88. Hockey stick appearance in echocardiography is a feature of Mitral stenosis Mitral incompetence Aortic regurgitation Aortic stenosis 89. the sigmoid nature of Hb-O2 dissociation curve is because of hemoglobin is acidic in nature beta chain has more affinity for alpha chain binding of one O2 molecule increase the affinity for the next O2 molecule alpha chain has more affinity for O2 than beta chain 90. During management of ventricular fibrillation , what is true about use of vasopressin First line drug of choice Used with adrenaline Use every 3 minutes Never used 91. Immunoglobin, which is produced first by the fetus in response to Infection IgA IgD IgG IgM 92. nitrogen narcosis is caused due to decrease in oxygen free radicals nitrogen inhibits dismutase enzyme increase solubility of nitrogen in nerve cell membrane increase production of nitrous oxide 93. Complement binding Immunoglobin via the classical pathway is – IgG & IgD IgD & IgE IgG & IgA IgG & IgM 94. If diameter of a vessel is doubled Blood flow increases four fold Blood flow increases sixteen fold Blood flow decreases four fold Blood flow decreases sixteen fold 95. Schwannoma of spinal nerve roots is seen in Turcot syndrome Li-Fraumeni syndrome Neurofibromatosis 1 Neurofibromatosis 2 96. life span of RBC is 14 days 1 year 100 days 3 years 97. The exact part of the antigen that reacts with the immune system is called as Idiotope Epitope Paratope Clone 98. Which of the following anti-diabetic drugs can be used safely in renal failure Canagliflozin Metformin Linagliptin Sitagliptin 99. In uncompensated diabetic ketoacidosis pCO2 increases HCO3 decreases Ratio of pCO2 to HCO3 decreases pH of blood>7.35 100. Which of the following is decreased as a result of hyperventilation? Cerebral blood flow Arterial pH Arterial oxygen content Arterial oxygen tension (PO2) 101. Decreased basal metabolic rate is seen in: Obesity Exercise Feeding Hyperthyrodism 102. The oxygen-hemoglobin dissociation curve shifts to the left under which of the following circumstances? Carbon monoxide poisoning Decreased pH Increased temperature Increased 2,3-diphosphoglycerate (2,3-DPG) D. Increased PCO2 103. regarding transport of substances through the cell membrane all are true except glucose is transported via facilitated diffusion active transport is an energy deriven process facilitated diffusion requires energy facilitated diffusion requires carrier protein 104. Salivary amylase is activated by HCO3 K+ Na+ Cl 105. Generalized edema is known as: Anasarca Hydropericardium Hydrothorax Ascites 106. Nitrogen washout method is used for estimating Functional residual capacity Tidal volume Diffusion capacity Dead space volume 107. interference with oxygen exchange in lungs is a type of anoxic anoxia hypoxic hyoxia histotoxic hypoxia anoxemia 108. All of the following statements are true regarding reversible cell injury, except – Diminished generation of adenosine triphosphate (ATP). Detachment of ribosomes from the granular endoplasmic reticulum. Formation of amorphous densities in the mitochondrial matrix. Formation of blebs in the plasma membrane. 109. Which type of necrosis listed below is the basic and most common type? Liquefactive necrosis Gaseous necrosis Gangrenous necrosis Coagulative necrosis 110. A 39-year old female presents with fever. The blood culture from the patient grows gram positive small to medium coccobacilli that are pleomorphic occurring in short chains. Direct wet mount from the culture shows tumbling motility. The most likely organism is Listeria monocytogenes Erysipelothrix rhusiopathiae Corynebacterium species Enterococcus species 111. Pneumococcus can be differentiated from streptococcus by Gram staining Growth characteristics Type of hemolysis Bile solubility 112. Episodic generalized weakness is related to all except: Hypocalcemia Hypokalemia Hypophosphatemia Hyponatremia 113. Wheel chair sign is seen in Beckers dystrophy Thomson disease Duchenne muscular dystrophy Parkinsonism 114. Doppler ultrasound, all are true except? Direction of blood flow Degree of stenosis Monophasic tracing measure normal flow Provide information about blood velocity 115. All of the following drugs are used in pituitary adenoma except Octreotide Orlistat Letrozol Bromocryptine 116. mean circulatory filling ressure is mean arterial pressure diff between central venous pressure and central arterial pressure arterial pressure taken at the point when heart stops beating difference between systemic and pulmonary arterial pressure 117. Jaundice refers to yellow discoloration of the skin, sclera, and tissues caused by: Hyperbilirubinemia Hypercaicemia Hyperlipidemia Hyperglycemia 118. Carbon dioxide is transported in blood by a variety of mechanisms.Which of the following is quantitatively the most important method for transporting CO2? As sodium bicarbonate in serum As CO2 in gas bubbles As CO2 in physical solution As carbaminohemoglobin 119. Role of bile salts Emulsification of lipids Formation of lipid bilayer Fatty acid degradation Vit B12 absorption 120. The cells which have the capacity to multiply throughout their Life None of the above Labile cells Permanent cells Stable cells 121. In a 70 kg adult, the fasting blood sugar level is 180 mg/100m1. This is indicative of Ketosis Hypoglycemia Ketoacidosis Hyperglycemia 122. all are second messengers ecept DAG cAMP IP3 guanyl cyclise 123. Component of tubercle bacilli which produces granuloma is Hetero polysaccharide Sulfadase Sulfatide Surface glycolipids 124. All of the following are potential pathogens of ororpharynx except: H. influenzae Streptococcus pneumonia N. Meningitides E.coli 125. A protoplast is best described as a bacterial cell Free of cell wall and capsule With a cell wall but free of capsule Uniquely sensitive to penicillin Containing a cell wall and a capsule 126. Investigation of choice to diagnose epilepsy Angiogram CT Scan EEG MRI 127. Windkessel effect in large arteries perform what function Prevent fluctuation in BP Maintain intravascular volume provide peripheral resistance Exchange of respiratory gases 128. C ‘wave in JVP is due to Atrial contraction Atrial filling with tricuspid valves closed Bulging of tricuspid valve into the right atrium Rapid right ventricular filling 129. During normal diastole, which of the following is most important in preventing over- distension of the ventricles? Adjacent lungs Aortic valve Diaphragm Fibrous pericardium 130. an important non respiratory function of lungs is calcium balance potassium balace sodium balance anion balance 131. Acromegaly is Excessive growth caused by the oversecretion of epinephrine Excessive growth caused by the oversecretion of growth hormone Excessive growth caused by the oversecretion of parathyroid hormone Excessive growth caused by the oversecretion of thyroid hormone 132. GFR measurement help in determining Heart rate Stage of kidney disease Recovery from shock Blood volume 133. In poorly controlled Type I diabetes, most common infection is: Rhinosporidiasis Histoplasmosis Mucormycosis Cryptococcus 134. physiolgical response to smoking are all except decreased HDL increased heart rate and increased catecholemine release increased hematocrit decreased carboxyhemoglobin 135. Diabetes mellitus affects all except: Heart Kidney Lung Brain 136. Chymotrypsinogen is a Carboxypeptidase Transaminase Zymogen Elastase 137. maximum potassium ions secretion is seen in jejunal secretion colonic secretions saliva gastric secretion 138. Characteristic feature of retiovirus is: Restriction endonuclease Ribonuclease Reverse transcriptase DNA polymerase 139. A patient is admitted in casualty with signs of fever, lymphadenopathay etc. Investigations reveal infection by pseudomonas aeruginosa. Drug of choice includes Doxycycline Ceftriaxone Cefalexin Piperacillin + Tazobactam 140. In classification of Obstructive sleep apnoea (OSA), a severe case is defined as when the number of episodes of apnoea during sleep exceed >30/ hour 10/ hour 25 / hour 15 / hour 141. Which of the following drug is not used for management of acute pulmonary oedema Dobutamine Phenylephrine Dopamine Norepinephrine 142. Cardiovascular effects seen in AIDS are all except Pericardial tamponade Recurrent arterial embolism Aortic aneurysm CHF 143. normal pH of stomach is 11 to 12 4 to 5 8 to 9 7 to 7.2 144. Following is given with iron to increase its absorption Antacids Milk Citrus fruits Alkalies 145. Release of neurotransmitter from presynaptic vesicles is an example of Exocytosis Simple diffusion Facilitated diffusion Active transport 146. Largest reserve of energy in body stored as Adipose tissue Liver glycogen Blood glucose Muscle glycogen 147. vit K dependent clotting factors are 3,10,12 3,6,8 2,7,9,10 7,9,10 148. Fungus affecting reticular endothelial system Mucormycosis Rhizopus Histioplasma capsulatum Cryptococcus neoformans 149. during diastole the arterial pressure is maintained by contraction of left ventricle musculature of arteries constriction of capillaries elastic recoil of aorta 150. Filgrastim is used for treatment of Polycythemia Neutropenia Anemia Neutrophenia 151. Ocular bobbing is seen in mid brain damage Cerebellum damage Pontine damage Medulla damage 152. Which of the following bone malignancies is most fatal: Osteosarcoma Pagets disease Multiple myelorna Giant cell tumor 153. Most important factor in transport across a membrane Size of particle Concentration gradient membrane thickness Charge of particle 154. Techoic acid is present in Cytoplasm of Gram negative organisms Cytoplasm of Gram positive organisms Cell wall of Gram positive organisms Cell wall of Gram negative organisms 155. constitutive component of pulmonary endothelium cells lipoprotein lipase thrombin plasminogen activator factor X 156. Acute infection causes: Leucopenia Neutropenia Monocytosis Leucocytosis 157. carbon monoxide transfusion in lungs is diffusion limited as pCO2 rises in blood immediately on exposure base of lung is poorly ventilated diffusion of CO across blood barrier is slow carboxy hemoglobin has high avidity 158. Purkinje fibres are Modified cardiac muscle Modified nerve fibres Fibrous tissue Modified smooth muscle 159. Which of the following controls the salivary secretion? CCK Parasympathetic nervous system Gastrin Secretin 160. decreased basal metabolic rate is seen in obesity hyperthyroidism feeding exercise 161. Which of the following is a true statement? Calcalour white stains acanthamoeba red grain positive bacteria appear black Gram negative bacteria appear .red in Gram staining Gomori- Methanamine silver stains the fungus Pneumocystis jiroveci green 162. all of the following antibacterial proteins are secreted from primary granules except lactoferrin defensins bacterial permeability increasing proteins lysozyme 163. Proximal convoluted tubule have which type of aquaporins Aquaporin 9 Aquaporin 5 Aquaporin 1 Aquaporin 2 164. Organism most resistant to sterilization: Mycobacteria Fungus Prions Spores 165. A patient in emergency with symptoms of tachycardia bronchodilation increased temperature and constipation .He may be suffering from poisoning with Mushroom Organophosphorus Atropine Penicillamine 166. which of the following is absorbed in stomach alcohols salts amino acids fatty acids 167. Difference in transudate and exudate is that the former has a: Increased specific gravity High protein Cloudy appearance Low protein 168. Which stage of plasmodium vivax is infective for mosquito? Sporozoite Gametocyte Trophozoite Ookinete 169. Nucleus in reticulocyte is: Compact Absent Fragmented Pyknotic 170. Nephrotic syndrome causes: Hypermagnesemia Hypercalcemia Hypokalaemia Hyperkalaemia 171. in a healthy patient the spaces between the body contain water loose connective tissue air fibrous connective tissue 172. A 29 yrs old woman with a pregnancy of 17 week has a 10 years old boy with down syndrome. She does not want another down syndrome kid; best advice to her is Ultra sound at this point of time will definitely tell her that next baby will be down syndromic or not Amniotic fluid samples plus chromosomal analysis will definitely tell her that next baby will be down syndromic or not blood screening at this point of time will clear the exact picture No test is required now as her age is below 35 years 173. which of the following enzyme is stable at acidic pH pepsin trypsin carboxypeptidase chymotripsin 174. All of the following clinical features are associated with enteroviruses Hemorrhagic fever Myocarditis Pleurodynia Herpangina 175. Golf ball inclusion bodies in RBC are seen in Normal reticulocytes pernicious anemia HbH disease G6PD deficiency 176. Kidney stones (renal calculi) are a common complication in a patient with which disorder listed below? Hyperparathyroidism Hypopituitarism Diabetes mellitus Hyperthyroidism 177. Regarding leptospirosis all are true except: Lice act as reservoirs of disease Humans are the end hosts It is a zoonosis Humans are accidental hosts of the disease 178. First sensation to be lost in leprosy Pain Temperature Touch Pressure 179. Causative organism for gas gangrene Clostridium welchii Clostridium tetani Strep. Faecalis E. Coli 180. Rapid correction of severe hyperglycemia only by insulin causes: Hypokalemia Hypernatremia Hyperkalemia Hyponatremia 181. Tuberculin test screens for Humoral immunity Complement function Phagocyte dysfunction Cell mediated immunity 182. Which of the following regions of the nephron is capable of the greatest level of glucose reabsorption? Distal convoluted tubule Proximal convoluted tubule Collecting duct Thick ascending limb of loop of henle 183. Most potent stimulator of naive T cells is: Epithelial cells Follicular dendritic cells Immature dendritic cells Macrophage 184. Treatment of asymptomatic bradycardia is No treatment is required Cardiac pacing Give atropine Isoprenaline 185. Most common cause of Resistant hypertension is Renovascular disease Non compliance of patient Pheochromocytoma Obstructive sleep apnea 186. Which of the following is true about streptococcus pneumoniae: Gram -ve diplococcic Gram +ve coccobacilli Extracellular grain -ve diplococcic Gram +ve Lanceolate diplococci 187. First released Immunoglobulin after primary immunization IgG IgE IgD IgM 188. Which is not seen in Cushing’ syndrome: Hypoglycemia Hypertension Poor wound healing Osteoporosis 189. Bone lytic lesions along with increase in B-cells derived from hyperplastic bone marrow are seen in: Hodgkins lymphoma Multiple myeloma Thallasemia Plasmacytoma 190. Effector region of immunoglobulin is Constant region of light and heavy chain Variable region of light and heavy chain Variable region of heavy chain Constant region of heavy chain 191. christmas disease occurs due to deficiency of factor IX factor X factor VIII factor XI 192. Effusion in TB is characterized by: High glucose Protein >3 gm/dL Effusion LDH/Serum LDH= < 0.6 Few cells, 193. Mid systolic click is classically heard in Hamman-rich syndrome Congenital Mitral stenosis Rheumatic aortic regurgitation Mitral valve prolapsed 194. which of the following statements is true if clearance of substance is greater than GFR then tubular secretion must be present descending limb of loop of henle is permeable to solutes fluid coming from the descending limb of loop of henle is hypotonic clearance of a substance is always more than GFR if there is tubular secretion 195. Sulfonylureas acts by: Increasing cell sensitivity Ca+2 channel activation K+ channel closure Activating DPP-4 196. intrinsic factor of castle is secreted by which of the following cells in gastric glands enterochromaffin cells B cells parietal cells chief cells 197. Hemophilia A is caused by defect of gene encoding: Factor 9 Factor 8 Factor 5 Factor 13 198. The most appropriate drug use for chelation therapy in beta thalassaemia major is oral desferrioxamine Oral succimer Intramuscular EDTA Oral deferiprone 199. which of the following is the active form of calcium in circulation phosphate bound calcium ionized calcium albumin bound calcium protein bound calcium 200. Extrahepatic cholestasis causes: Increased urobilinogen in serum increase bilirubin in both urine and serum Increased bilirubin in urine Increased urobilinogen in urine 201. bile acid pool circulates twice between meals 4 times per meal 10 times per day on fasting 8 times per day 202. The following hepatitis virus is transmitted by faeco-oral route: except Hepatitis D Virus Hepatitis B Virus Hepatitis E Virus Hepatitis C Virus 203. Chemoreceptors are located in which area Arch of aorta Bifurcation of carotid artery All of the above Medulla 204. Rothera’s test is used to detect: Carbohydrate Fat Ketone bodies Protein 205. Blood pressure is difficult to measure in a patient with Complete heart block Mitral stenosis Atrial fibrillation Aortic stenosis 206. In a pregnant woman, which of the following vaccines is not indicated Hepatitis B MMR DPT Rabies 207. With regards to temperature requirement, most pathogenic bacteria are: Psychrophiles Ciyophiles Thermophites Mesophiles 208. All are true regarding Donavanosis except: Causes painful ulcerative genital lesions Syphilis can occur concomitant with it The causative organism is Calymmatobacter granulomatis Endemic in tropical areas 209. which of the following is not a primary taste chilli sweet bitter sour 210. Stain used for histologic demonstration of candida hyphae Acridine orange Carbol fuschin Hematoxylin & Eosin PAS 211. All of the following are possible causes of tetany, except: Hyperventilation Rickets (Vitamin D deficiency) Hypertension Hypoparathyroidism 212. Each of the following is a risk factor in atherosclerosis EXCEPT one.Which one is this EXCEPTION? Hypertension Heredity Diabetes mellitus Alcoholism 213. Percentage of Total body water to total body weight at birth is 90 percentage 60 percentage 80 percentage 50 percentage 214. Branchial cyst opens most commonly in which area: Opposite 3rd molar Opposite 2nd molar Behind palatopbaryngeal arch Tonsillar fossa 215. Cross beta-pleated sheet structure in amyloidosis is determined by: Light microscopy X-ray crystallography Electron microscopy Polarized microscopy 216. Phagocytosis enhanced by coating the surface of antigen is called Opsonisation CFT Decoding Chemotaxis 217. Which of these is true about antibodies: Secretory part of IgA is synthesized by plasma cells IgE mediated delayed hypersensitivity IgM is seen in secondary response IgM is an acute phase reactant 218. which of the following is not involved in intrinsic pathway factorXI factor XII factor IX factor VII 219. Sterilization cycle uses: 170 degrees Celsius, 25 psi, 10 min 121 degrees Celsius, 15 psi, 15 min 160 degrees Celsius, 20 psi, 15 minutes 180 degrees Celsius, 15 psi, 15 min 220. Endotoxic shock is initiated by Peripheral vasodilatation inadequate blood voumes failure of myocardial pump injury to endothelial cells 221. Insulin resistant DM: Type II All DM are sensitive to insulin Type I Juvenile onset 222. Which of the following is not used as disinfectant for skin preparation due to its irritation potential: Alcohol Hypochlorite Hexachloropropane Hexidine 223. The single most important laboratory test for determining the virulence of staphylococci is Hemolysis of sheep erythrocytes The catalase test Mannitol fermentation Detection of coagulase 224. Angiotensin II causes all of the following, except Vasodilatation Increased ADH secretion Stimulation of thirst Aldosterone secretion 225. Bile acids consist of all except Taurocholic acid Lithocholic acid Chendeoxycholic acid Deoxycholic add 226. Which of the following procoagulant proteins binds to tissue factor exposed beneath the endothelium of traumatized blood vessels and initiates the clotting cascade? Factor X Factor V Factor VII Fibrinogen 227. Which of the following drugs used for diabetes melitis causes lactic acidosis Glipizide Pioglitazone Phenphormin Metformin 228. Opacity around colonies of Clostridium perfringens is due to – Desmotase Lecithinase Cytokinin Theta toxin 229. Incorrect about Lafora’s disease Treatment with glucocerebrosidase infusions Diagnosis by DNA sequencing Myoclonus Autosomal recessive 230. Virchow’s triad consists of all except: Hypercoagulability Vascular stasis Platelet plug Endothelial injury 231. Both intranulear and intracytoplasmic inclusions are present in which of the following viruses Hepatitis B virus Pox Virus HIV Measles virus 232. Iron absorption takes place in which part of intestine Ileum jejunum Colon Duodenum 233. Acute infection causes: Leucocytosis Monocytosis Leucopenia Neutropenia 234. Cerebral perfusion pressure is Arterial pressure minus intracranial pressure Arterial pressue x venous pressure Venous pressure minus arterial pressure Arterial pressure minus peripheral venous pressure 235. somatomedian mediates lipolysis gluconeogenesis decreased rate of glucose uptake by cells deposition of chondroitin sulphate 236. Hematologic investigations of PT/INR are useful to detect defects in: Only extrinsic pathway Extrinsic and common pathway lntrinsic and common pathway Only intrinsic pathway 237. ST segment of ECG corresponds to AV conduction Atrial depolarisation Ventricular repolarisation Ventricular depolarization 238. Tachycardia, nervousness, intolerance to heat and exophthalmos are seen in Hypoparathyroidism Hypothyroidism Hyperparathyroidism Hyperthyroidism 239. Differential leucocyte count is used for diagnosis of: Eosinophilia Leukocytosis Anemia Leukopenia 240. A nursing staff while putting IV line to a seriously ill patient of HIV accidentally got a needlestick injury. Which of the following investigation will be most appropriate for her ELISA test Western blot P24 antigen capture assay Blood culture Loading …
