NEET MDS UNIT Test – Oral medicine, Biochemistry, pharmacology, general medicine #1

1. Tetracycline acts by inhibiting protein synthesis at:

2. Folding of protein chain is due to

3. The protein rich in basic amino acids, which functions in the packaging of DNA in chromosomes, is

4. Therapeutic drug monitoring is required in all except

5. Eosinophilic granulomas

6. insulin causes lipogenesis by all except

7. TSH, LH, FSH act by

8. GNAS1 Gene mutation is associated with

9. Which of the following is true about hypophosphatasia

10. Which valve is most affected by rheumatic fever

11. Which of the following anomaly needs consideration in restorative treatment?

12. Which of the following bone malignancies is most fatal:

13. A nursing staff while putting IV line to a seriously ill patient of HIV accidentally got a needlestick injury. Which of the following investigation will be most appropriate for her

14. Major source of ammonia in the kidney is

15. Which one of the following intravenous induction agents is the most suitable for day care surgery

16. What is NOT true for selective COX-2 inhibitor is

17. Edman’s reagent is

18. Most important factor for calculating dose of NSAIDS in children

19. Which one of the following clinical findings excludes the diagnosis of polymyositis

20. Substrate for ATP synthase is-

21. Golf ball inclusion bodies in RBC are seen in

22. In oxidative phosphorylation, the ATP production and respiratory chain are linked by-

23. When 2 drugs A and B are compared false statement is

24. Not true of obstructive sleep apnea

25. Role of molecular change in ETC is-

26. In steady state model of metabolism A->B->C->D, which of the following is true

27. Ground glass appearance, Brown tumors and hypercalcemia are seen

28. Which of these is most effective for gluconeogenesis

29. If a person is having ventricular tachycardia,extra systoles appears in

30. Blood pressure is difficult to measure in a patient with

31. A 29 yrs old woman with a pregnancy of 17 week has a 10 years old boy with down syndrome. She does not want another down syndrome kid; best advice to her is

32. The therapeutic efficacy of antihypertensive drugs is blunted by NSAIDS because they

33. In prolonged starvation the main energy source of brain is

34. Sialologue is an agent used to

35. Which of the following anti-diabetic drugs can be used safely in renal failure

36. Mechanism of action of chloramphenicol is

37. Appearance of red macules with, ‘herald sign’ appearing 7-10 days back, 3-4 cm in diameter, shiny ovoid along with skin lumps with silvery sheen is a characteristic of:

38. Least energy producing cycle

39. which of the following is present in plasma but absent in serum

40. Which of the following drug is not used for management of acute pulmonary oedema

41. Use of aspirin in children with viral disease is associated with

42. A lady complaints her 9 year old daughter is suffering from oral ulceration, fever and shedding of skin from Palm and soles. She also provided history of premature exfoliation of teeth and increased sweating. She also gave history of using new teething gel available in market for past one month. Her daughter is most probably suffering from

43. Not a characteristic of white infarct:

44. Both ketogenic and glucogenic amino acid is

45. Albumin and globulin are classified as

46. Transport of ADP in and ATP out of mitochondria is inhibited by-

47. Mutation in which chromosome is related to dentinogenesis imperfect

48. Grapefruit juice is an

49. Ulthoff sign is seen in:

50. NADPH is produced by

51. In uncompensated diabetic ketoacidosis

52. Branchial cyst opens most commonly in which area:

53. Streptococci adhere to the oral suraces and contribute to caries development as they

54. The following is true about malaria

55. The following is not a carrier protein

56. Incorrect about Lafora’s disease

57. 25 years old asthmatic patient on theophyllline is given ciprofloxacin by dentist. He developed dyspnoea and palpitation. What could be the cause

58. Phocomelia is best described as

59. drug of choice for treatment of infection caused by methicillin resistant staphylococcus aureus is

60. a female patient showing progressive muscle and fat loss on the right side of the face is suffering from

61. A immunocompromised patient came to your clinic with complain of decreased salivary secretion and foul odor from mouth. On histopathological examination ,Acinar necrosis and squamous metaplasia of salivary duct where observed . what is the diagnosis

62. Hockey stick appearance in echocardiography is a feature of

63. All of the following drugs are used in pituitary adenoma except

64. A patient is admitted in casualty with signs of fever, lymphadenopathay etc. Investigations reveal infection by pseudomonas aeruginosa. Drug of choice includes

65. Which of the following antibiotic is used in the treatment of clostridium difficile associated diarrhea

66. Consider two patients with atherosclerosis, one is diabetic and other is non-diabetic. When compare to non-diabetic, diabetic patient has hundred times increased risk of

67. Syndrome associated with predisposition to development of oral cancer is termed as

68. Which of the HPV cause malignancy:

69. Which of the following is not a phase 1 reaction in drug metabolism

70. The most important parameter to monitor Dengue haemorrhagic fever is

71. A 60 years old patient having cardiorespiratory arrest in hospital ward, for oxygenation what should be done immediately?

72. calcification of falx cerebri is seen in

73. gluconeogenesis in fasting state is indicated by

74. Which of the following drug inhibits cell wall synthesis

75. Fluid of choice in infant diarrhoea

76. nephrometry is based on the principle of

77. You have to draw blood from a patient. When will you give EDTA?

78. Urinary protein is detected by

79. Not essential for brain death

80. Rofecoxib was withdrawn due to

81. Creatinine is formed from

82. Earliest marker of renal damage in a known case of diabetes mellitus is:

83. which of the following enzymes catalyse the irreversible steps of glycolysis

84. Wheel chair sign is seen in

85. A 10 year old has diffuse bilateral white areas on the buccal mucosa, dorsum of the tongue and the floor of the mouth. The mother tells the dentist that she has noticed this appearance for at least 3 years, but she was not concerned since she has had a similar condition all of her life. The most likely diagnosis is

86. Drug of choice in neonatal seizures

87. During management of ventricular fibrillation , what is true about use of vasopressin

88. Which of the following is NOT associated with osteogenesis imperfecta?

89. Storage form of free energy in the cell is-

90. Urea is produced by the enzyme

91. Continuous murmur is seen in all of the following conditions except

92. Which anti tubercular causes reversible Red Orange Urine:

93. Maximum energy is liberated by hydrolysis of

94. Proteins are seperated on the basis of charge in

95. An odour of acetone on the breath can be found in patients with

96. Which of the following is th metabolic pathway in which there is a shuttling of glucose and lactate between muscle and liver during physical exercise

97. Virchow’s triad consists of all except:

98. Most common intraoral infection in diabetic patient:

99. Most common cause of Mobius syndrome is use of which of the following drug in pregnancy

100. Blood transfusion associated acute lung injury occurs due to

101. In which of the following disease maternal antibodies are not protective to the child

102. all the statements regarding LDL receptors are true except

103. Activity of which of the following enzyme is not affected by insulin

104. Bacteriostatic antitubercular drug is

105. APGAR score is a quantitative method of assessing score of new born status based on

106. Drug of choice in opioid withdrawal:

107. A 4-year-old patient comes with her mother for a routine appointment. The mother states that her daughter just started not feeling well and had a mild fever earlier in the day. The daughter has been having trouble swallowing. An intraoral exam reveals multiple 1-mm to 2- mm vesiculopapular lesions of the nasopharynx and soft palate. Your working diagnosis is:

108. which amino acid migrates faster on paper chromatography on methyl cellulose medium

109. antinuclear antibody is found in

110. Time dependent killing and prolonged post antibiotic effect is seen with

111. Citrate to cis aconitate conversion is inhibited by

112. To differentiate between hemifacial hypertrophy and unilateral fibrous dysplasia of the maxilla evaluation of which of the following would be most useful

113. Negative regulator of BMP is

114. Which of the following drugs used for diabetes melitis causes lactic acidosis

115. A distinctive advantage of tetracycline over penicillin is that tetracyclines

116. Along with INH which vitamin is given

117. Fluconazole resistant candidiasis in a HIV positive patient is treated by

118. One of the following is not penicillinase susceptible

119. Tongue shows loss of normal exfoliation of surface epithelium with hypertrophy of filiform papillae in:

120. Which of the following is a precursor of protoporphyrin

121. Which amino acid is not involved in transamination

122. Most common cause of Resistant hypertension is

123. Glucose transporters present in the beta cells of the Islet of Langerhans is

124. during phagocytosis the metabolic process called respiratory burst involves the activation of

125. Hematologic investigations of PT/INR are useful to detect defects in:

126. Drug of choice for pseudomembranous enterocolitis

127. which of the following cyst shows maximum amount of recurrence

128. Which of the following drugs is used to prevent HIV transmission from HIV positive pregnant mother to child

129. Cyclooxygenase enzyme is not inhibited by

130. All are vasodilators except

131. Schwannoma of spinal nerve roots is seen in

132. A patient with severely displaced teeth,fractured enamel ,undefined DEJ and severe attrition may be suffering from

133. Ocular bobbing is seen in

134. Natal and neonatal teeth are not associated with

135. burning tongue will not be associated with which of the following

136. Investigation of choice to diagnose epilepsy

137. Glucose 6 phosphatase deficicency is seen in

138. GLUT-5 is transporter for

139. a person with von Gierke’s disease has ketosis. All are true for ketosis in this patient except

140. Miescher syndrome is associated with

141. Herpes zoster is caused by

142. dermatotropic viral diseases are

143. All are caused by amino acid deficiency except

144. Therapeutic index is a measure of

145. Lactate produced anaerobically is used by

146. collagen is rich in

147. Cross resistance of isoniazid is seen with

148. All of the following statements about opioids is correct except

149. Involucrum is

150. which one of the following shows dense collagenous stroma with compressive thin strands and cords of epithelium cells

151. which one of the following shows ‘blueberry lips’

152. Loading dose depends upon

153. 20% KOH used in the diagnosis of candida albicans. Its mechanism of action is

154. Glutamine replaced by valine in sickle cell anemia is characterised by

155. APC gene is mutated in

156. Papillary hyperplasia under a denture is usually due to (an)

157. Perioral freckles with risk of breast cancer and intestinal cancer is a feature of:

158. What drug competes with bilirubin to bind with albumin:

159. In which type of glycogen storage disease is hyperuricemia a feature

160. Fissured tongue is seen in:

161. Which of the following is not an intermediate of citric acid cycle

162. cell differentiation by surface markers

163. Mid systolic click is classically heard in

164. The ground substance of the extracellular matrix is made up of

165. True regarding dentigerous cyst is all except

166. Which of the following is not seen in secondary adrenal insufficiency

167. Key enzyme in glycogenolysis

168. A positive Nikolsky’s sign is a diagnostic feature of

169. A 40 years old lady reported with history of pain in right cheek since the last 2 months. The pain is sharp, lancinating and sudden in onset and brief in duration. The attacks are triggered by chewing foo She is normal in between the attacks. What is the diagnosis:

170. The characteristic feature seen during the histogic examination of a langerhans cell histiocytosis lesion is

171. Cardiovascular effects seen in AIDS are all except

172. Co prescription of amoxicillin with clavulanic acid is an example of

173. Doppler ultrasound, all are true except?

174. A patient in emergency with symptoms of tachycardia bronchodilation increased temperature and constipation .He may be suffering from poisoning with

175. Drug of choice of malignant hyperthermia

176. Which of the following acts by inhibiting cell wall synthesis:

177. Glycogen breakdown leads to formation of

178. Which of these is not a cofactor for glycogen phophorylase, an important enzyme of the glycogenolysis pathway

179. Glycine is used for synthesis of the following except

180. Patient is suffering from atherosclerosis. Which of the following is the most beneficial drug for prevention of stroke in this patient

181. increased levels of alanine in serum after fasting suggests

182. Hutchison triad includes all of the following except

183. First sensation to be lost in leprosy

184. Amide group is present in which part of protein

185. Which is not a monosaccharide

186. In a pregnant woman, which of the following vaccines is not indicated

187. In leprosy, the best bactericidal agent is

188. Safest 1st line ATT in renal failure is

189. spreading enzyme produced by some species of streptococcus

190. Local anaesthetic used as an antiarrhythmic agent is

191. Hairy tongue is associated with hypertrophy of:

192. Which of the following antibacterial drug is not used in the treatment of malaria

193. Inhibition of glycolysis by oxygen is known as

194. which of the following is the major contributor to colloid osmotic pressure

195. The conversion of an optically pure isomer (enantiomer) into a mixture of equal amounts of both dextro and levo forms is called as

196. Most common cause of nephrotic syndrome in adults:

197. 5HT1 agonists are used as

198. Regulating enzymes in gluconeogenesis are all ,except

199. Which can be given safely in renal failure

200. antigen associated with cicatricial Pemphigoid

201. which of the following reactions does not convert hydrophobic into hydrophilic groups

202. Cervical cancer caused by:

203. which of the NSAID can be used by parenteral route

204. the 40nm gap in between the tropocollagen molecule in collagen which serve as the site of bone formation is occupied by which of the following

205. The most appropriate drug use for chelation therapy in beta thalassaemia major is

206. Multiple supernumerary teeth are most commonly found in

207. In citric acid cycle,NADH is produced by

208. Which of the following techniques can be used for exact localisation of a genetic locus

209. True about polio

210. A post operative patient developed septicaemia and was incorrectly started on combination chemotherapy by a new resident doctor. However, when the patient did not respond even after 10 days of antibiotics treatment, the review of the charts was done. It was found that the resident doctor had started the combination of antibiotics which was mutually antagonistic in action. Which one of the following is the most likely combination that was given

211. Best test for mycoplasma infection is

212. rheumatoid arthritis, SLE, thyroiditis are examples of

213. Enzyme common between glycogenesis and glycogenolysis

214. Treatment of asymptomatic bradycardia is

215. Drug of choice in a patient with renal disorder and Vancomycin resistant MRSA:

216. Co-factor for L-amino acid oxidase is

217. Citrate synthesase is inhibited by

218. Which of the following metabolic pathway in carbohydrate metabolism is required for synthesis of nucleic acid

219. Filgrastim is used for treatment of

220. Which of the following is an aldose

221. All of the following anticancer agents cause bone marrow depression except

222. A child reports with greenish stains on teeth .The most probable cause is

223. What is true about Tramadol:

224. Amcloblastoma originates from:

225. Fructose intolerance is to

226. The direct immunoflourescence pattern seen in pemphigus vulgaris has been described as

227. a condition caused by excess of steroid hormone cortisol in the blood level which is caused by pituitary tumor secreting adrenocorticotropic hormone is

228. granulomatous gingivitis shows histopathology similar to

229. “shivering” is observed in the early part of postoperative period due to

230. Citrullinemia is due to deficiency of

231. Drug given for emergency treatment of angina in a patient with ischemic heart disease

232. Most common structure compressed by aneurysm of posterior communicating artery in the circle of Willis

233. Reducing equivalents produced in glycolysis are transported from cytosol to mitochondria by

234. Which of the following is not true about from a transfusion related acute lung injury

235. The most prominent toxic effects associated with acetaminophen use is

236. which one of the following does the bisphosphonates primary cause

237. Herpetic koilonychia is herpetic infection of

238. Which is the most common manifestation of recurrent HSV1 infection

239. Which of the following agent causes interstitial nephritis

240. Which of these is used as a marker of proliferation ( dysplastic proliferation) in a premalignant lesion: