1. chymotrypsinogen is atransaminasescarboxypeptidaseelastasezymogen 2. Co-factor for phosphofructokinase isMgMnFeZn 3. which of the following is used to detect the chromosomal differences between neoplastic cells and their normal counterpartsPCRComparative genomic hybridizationSpectral karyotypingwestern blotting 4. The most common pathway of glycolysisEntner Doudoroff pathwayEmbden Meyerhof pathwayPentose phosphate pathwayUrea pathway 5. Which of the following serves as a principal source of carbon for nonessential amino acidsfatswatercarbohydratesurea 6. Cabbage-like odour is seen inAlkaptonuriaPhenylketonuriaHartnup diseaseTyrosinemia 7. Rancid butter smelling of urine is seen inAlkaptonuriaPhenylketonuriaHartnup diseaseTyrosinemia 8. Alkaptonuria an inherited metabolic disorder is due to defiiciency ofHomogentisate oxidaseCystathionasePhenylalanine hydroxylaseTyrosine transaminase 9. "Classical phenyl ketonuria" is caused by deficiency ofPhenylalanine transaminasePhenylalanine hydroxylaseTyrosine transaminaseTyrosine hydroxylase 10. Imidazole ring is present inTryptophanArginineHistidineTyrosine 11. type of collagen present in hyaline cartilage istype Itype IItype IIItype IV 12. replacing alanine by which amino acid will increase UV absorption of protein at 280um wavelengthleucineprolineargininetryptophan 13. Which of the following is not a technique for protein precipitationTrichloroacetic acidHeat precipitationIsoelectric point methodtitration with reducing sugar 14. Transport proteins areFibrous proteinsGlobular proteinsBulky proteinsThreaded proteins 15. Which vitamin is essential for metabolism of sulphur containing amino acidsBiotinFolic acidVitamin CThiamine 16. hydroxylation of phenylalanine to tyrosine requiresTetrahydrofolatePyridoxal phosphateS-adenosyl methioninetetrahydrobiopterin 17. Lactate is formed in all exceptRBCsLensBrainTestis 18. Xylitol is aNatural sweet amino acidSynthetic sweet amino acidnatural five carbon sugarsynthetic five carbon sugar 19. All of the following are reducing sugars exceptGlucoseLactoseMaltoseSucrose 20. Allosteric inhibitors of TCA Cycle are all exceptADPATPNADHSuccinyl CoA 21. Malonate competetively inhibitsFumarate dehydrogenasesuccinate thiokinaseAconitaseSuccinate dehydrogenase 22. Urea is synthesized in all exceptLiverBrainKidneySpleen 23. hemoglobin estimation is done by all exceptdrabkin'swintrobessahli'sspectrophotometry 24. which of the following is seen in association with membrane raftglycosylphosphatidylinositol anchored proteinmannose binding proteinguanosine triphosphate associated proteinspectrin associated protein 25. Why citric acid cycle called amphibolic pathwayBoth exergonic and endergonic reactions takes placeMetabolites are utilised in other pathwaysIt can proceed both in forward and backward directionSame enzymes can be used in reverse directions 26. Rate limiting step in HMP shuntGlucose -6-phosphate to 6phosphogluconolactone6phophogluconolactone to 6 phophogluconate6-phosphogluconate to ribulose-5-phosphateRibulose-5-phosphate to Xylulose-5-phosphate 27. The common precursor of all three aromatic amino acids isChorismatePhosphoenolpyruvateshilkimateribose 5 phosphate 28. Most lipogenic carbohydrate isfructoseglucosegalactoseribose 29. Wernicke's encephalopathy is caused by deficiency ofThiamineCyanocobalamineNiacinRiboflavin 30. Prolonged carbohydrate deficiency leads toMetabolic alkalosisketoacidosisvitamin C deficiencyrespiratory acidosis 31. A cell membrane is damaged by insertion of a microneedle. Repair of the membrane occurs byHydrophobic interactionsProtein interactionsan active process requiring hydrolysis of ATPrequires enzymatic action 32. all of the following are true regarding oxygenases exceptincorporate 2 atoms of oxygenincorporate 1 atom of oxygenrequired for hydroxylation of steroidsrequired for carboxylation of drugs 33. fluorescence meansspontaneous illumination in darkrelease of longer wavelength light on absorbing light of shorter wavelengthrelease of shorter wavelength light on absorbing light of longer wavelengthrelease of equal wavelength light at constant rate 34. Histidine is converted to histamine byTransaminationHydroxylationDecarboxylationReduction 35. The glucose transporter which is stimulated by insulin is located inBrain and retinaLiver and beta cells of pancreasskeletal muscle and adipose tissueRBCs and intestine 36. ketones cannot be utilised bybrainheartskeletal muscleRBCs 37. Alpha helix and beta pleated sheet are examples ofPrimarySecondary structureTertiary structureQuaternary structure 38. Thiamine deficiency can cause lactic acidosis due to which enzyme dysfunction?PEP carboxykinasePyruvate carboxylasePhosphofructokinasePyruvate dehydrogenase(PDH) 39. Main enzyme involved in synthesis of GABAGlutamate dehydrogenaseGlutamate decarboxylaseCarboxymoyl-phosphate synthasePyruvate dehydrogenase 40. Which one of the following enzymes provides a link between glycolysis and the citric acid cycleLactate dehydrogenasePyruvate kinaseCitrate synthasePyruvate dehydrogenase 41. Unaltered final product of TCA cycleOxaloacetateAcetyl CoACO2Pyrovate 42. Pyruvate dehydrogenase requires all cofactors exceptThiaminRiboflavinNiacinPyridoxin 43. Maltose is aMonosaccharideDisaccharidePolysaccharideProtein saccharine combination 44. The primary role of chaperons is to help inprotein synthesisprotein degradationprotein denaturationprotein folding 45. The amino acid residue having an imino side chain isLysineHistidineTyrosineProline 46. for glucose estimation in blood the mode of transport from a PHC to lab issodium fluorideEDTAsodium citratepotassium oxalate and NAF 47. Leucine is a amino acid with aNon polar side chainPolar side chainNegatively charged side chainPositively charged side chain 48. Fructose 2-6 biphosphate isIntermediate of glycosisPositive allosteric regulation of PF1(phosphofructokinase 1)Negative allosteric regulation of PF1Positive allosteric regulation of PF2 49. serum creatinine is most accurately measured bykinematic jaffe techniquejaffe methodenzyme immunoassayplasma gel filtration 50. the structural proteins are involved in maintaining the shape of cell or in the formation of matrices in the body.the shape of these proteins isglobularfibrousstretch of beadsplanar 51. Histidine is the most important amino acid for buffering in normal conditions becauseIt regulates kidney acid-base balancePka value is higher than pHPka value is closer to pHPka value is very low 52. In glycolysis ATP is produced by the following enzymeHexokinasePhosphoglycerate kinaseEnolasePhosphohexose isomerase 53. Which of the following enzyme doesnot catalyse irreversible step in glycolysisHexokinasePhosphoglycerate kinasePyruvate kinasePhosphofructokinase 54. Fructose 2-6 bisphosphate regulates glycolysis at the level ofGlucose 6 phosphateFructose 6 phosphateGlyceraldehyde 3 phosphatePhosphoenol pyruvate 55. fireflies produces light due toNADHGTPATPphosphocreatine 56. Which of the following is caused by defective transport of tryptophanHartnup diseaseMaple syrup urine diseaseAlkaptonuriaPhenylketonuria 57. one of the following is not a precursor of adrenalinenor adrenalineisoprenalinedopaminephenylalanine 58. Hopkin Cole test is performed on proteins to detect the presence ofImidazole groupIndole groupGuanidine groupPhenolic group 59. True about denatured proteinsBiologically inactiveSoluble in waterPeptide bonds are hydrolysedPrimary structure of amino acid sequence is disrupted 60. The reducing equivalents for fatty acid synthesis are derived fromGlycolysisKreb's cycleUrea cyclePentose phosphate pathway 61. CO acts by inhibiting which component of respiratory chain-Cytochrome bCytochrome C oxidaseNADH CoQ reductaseOxidative phosphorylation 62. acids found in the citric acid (krebs) cycle areglutamic acid and succinic acidglucoronic acid and aspartic acidoxaloacetic acid and aspartic acidoxaloacetic acid and a-ketoglutaric acid 63. The end product of glycolysis under anaerobic conditions isLactic acidPyruvic acidacetoacetic acidOxaloacetic acid 64. During gluconeogenesis reducing equivaents from mitochondria to cytosol are transported byMalateAsparateOxaloacetateGlutamate 65. Rate limiting step in urea cycle is catalysed byArginaseArgininosuccinaseCarbamoyl-phosphate synthaseOrnithine transcarbamylase 66. Thermogenin is present in-CytoplasmMitochondriaRibosomeNucleus 67. Phenyl ketonuria is caused by defective metabolism ofcarbohydratesfatsamino acidsnucleic acids 68. Most important source of ATP is-Substrate level phosphorylationOxidative phosphorylationAnaerobic glycolysisNone of the above 69. Final common pathway of metabolism of carbohydrates, lipids an protein metabolism isTCA cycleGlycogenesisGluconeogenesisnone of the above 70. Role of selenocystein is important inHydroxylation of dopamineOxidation of drugsAntioxidant mechanismNone of the above 71. keratin is aGlobular proteinsCylindrical proteinsFibrous proteinsNone of the above 72. Which of the following is used to study protein-protein interactionWestern blotAffinity electrophoresisThin layer chromatographyNone of the above 73. The citric acid cycle is the final pathway for oxidation ofEnzymesVitaminsMineralsNone of the above 74. In TCA cycle , substrate level phosphorylation occurs atsuccinate dehydrogenasemalonate reductionthiokinaseNone of the above 75. Cori's cycle is concerned with transport ofAlanineGlutamateLactateNone 76. In the fasting state glucose is obtained fromLiver glycogenMuscle glycogenBothNone 77. Brain damage in phenylketonuria is due to accumulation ofTyrosinePhenylalanineTryptophannone 78. all are involved in fast axonal transport exceptkinesindyneinlysosomesneurofilaments 79. Which of the following cells in the body metabolise glucose only through anaerobic pathwaysMuscle cellsRed blood cellsHepatocytesNeural cells 80. True about glycolysis are all exceptProvides nutrition to cancer cellssubstrate level phosphorylation at pyruvate kinaseTwo carbon end product is formedNADPH is formed by glyceraldehyde -3-phosphate dehydrogenase 81. HMP shunt is of great importance in cellular metabolism because it producesATPADPAcetyl Co ANADPH 82. Source of energy in krebs cycle isNADNADPNADPHNADH 83. Coenzyme used in Kreb's cycle isNADNADPNADPHNADH 84. McArdles disease is due to deficiency ofGlucose 1 phosphataseGlucose 1,6 diphosphataseGlucose 6 phosphataseMyophosphorylase 85. Maple syrup urine disease is due toalpha-ketoacid decarboxylaseTransaminaseisomeriseMutase 86. Muscle cannot make use of glycogen for energy because of deficiency ofGlucokinasePhosphoglucomutaseG-6 phosphataseMuscle phosphorylate 87. starting material for production of insulin from bacteria isgenomic DNA from beta pancreatic cells of humangenomic DNA from lymphocytes of humanmRNA from beta pancreatic cells of humanmRNA from lymphocytes of human 88. Gluconeogenesis takes place inLiverRBCAdipocyteMonocyte 89. Which of the follwoing is not a test for amino acidsBiuret testXanthoproteic reactionNinhydrin testMolisch's test 90. protein is purifies using ammonium sulphate bysalting oution exchange chromatographymass chromatographymolecular size exclusion 91. Reaction occuring in conversion of norepinephrine to epinephrineHydroxylationOxidationGlucuronidationMethylation 92. A child was found to have hypoglycemia,hepatomegaly and accumulation of highly branched glycogen called limit dextrins.He is likely to be suffering fromCori's diseaseVon Gierke's diseaseAnderson's diseaseMcArdle's disease 93. in well fed state, the activity of CPT-1(Carnitine palmitoyl transferase) in outer mitochondrial membrane is inhibited byglucosepyruvateacetyl CoAmalonyl CoA 94. NAD+ acts as a conenzyme forXanthine oxidaseL-amino acid oxidaseSuccinate dehydrogenaseMalate dehydrogenase 95. Guanidinium group is associated withTyrosineArginineHistidineLysine 96. Not an essential amino acidArginineHistidineGlutamateLysine 97. Semi essential amino acid isHistidineAlanineLeucineLysine 98. insulin resistance is seen in patients with liver disease is due todamaged hepatocyteshepatic steatosisimpaired insulin releaselow c peptide level 99. Ketone bodies are formed only instomachkidneypancreasliver 100. the nitrogen of the body is suplied bytriacy glycerolproteinsglucoselipids Loading...