1. A patient comes to you complaining that whenever he takes aspirin for headache, he develops severe shortness of breath. Which of t the following may be partly responsible for this Prostaglandin E Leukotrienes Prostacyclin Thromboxane A2 2. Which of the following drugs is used to prevent HIV transmission from HIV positive pregnant mother to child Didanosine Nevirapine Stavudine Lamivudine 3. Xylometazoline is used before nasal intubation as it causes: Shrinkage of turbinates Dilation of nasal orifice/increasing chances of bleeding Vasoconstriction Relaxation of choanal opening 4. Amphotericin B causes deficiency of Calcium Sodium Chloride Potassium 5. Therapeutic drug index is used to assess Safety Efficacy Toxicity Potency 6. When 2 drugs A and B are compared false statement is If drug A produces more effect than maximum tolerable dose of drug B then A is more efficacious than B Dose and drug efficacy are not related If 1 mg of drug A has higher degree of same effect than 1 mg of drug B then A is more efficacious than B If 1 mg of drug A produces same effect as 3 mg of drug B then A is more potent than B 7. 40 year old patient was taking warfarin 4 gms for DVT prophylaxis. She was given ceftriaxone 8 hrs iv for dental infection. Later the lady experienced episode of vaginal bleeding and darkening of urine. What is the cause? Gut flora was inhibited by ceftriaxone ceftriaxone is an enzyme inducer ceftriaxone inhibits metabolism of warfarin Both have additional trombocytopenic effect 8. All are vasodilators except Procaine Lidocaine Chlorprocaine Cocaine 9. Which of the following action is ascribed to Delta type of opiod receptors Supraspinal analgesia Reduced intestinal motility Respiratory depression Euphoria 10. Misoprostol is a Antiprogestin Prostaglandin E 2 analogue Prostaglandin E1 analogue Prostaglandin antagonist 11. Main disadvantage of opioid analgesic: Urinary retention Mydriasis Diarrhea Dry cough 12. Which one of the following agents sensitises the myocardium to catecholamines Isofurane Halothane Ethane Propofol 13. When comparing opioids with NSAIDS which of the following is correct? NSAIDS cause more constipation. NSAIDS cause more drowsiness Opioids impair gastric motility to a greater extent. Opioids predispose to more bleeding. 14. Which of the following drugs inhibit an enzyme in the prostaglandin synthesis Aspirin Aminocaproic acid Aprotinin Alteplase 15. General anesthetics can do all of the following EXCEPT produce delirium. reduce perception of painful stimuli. stimulate medullary centers. produce a state of unconsciousness. 16. The persistent suppression of bacterial growth that may occur after limited exposure to some antimicrobial drug is called Time dependent killing Concentration dependent killing Sequential blockade Post antibiotic effect 17. Which of the following statement is not true about NSAIDS They interfere with the antihypertensives effect of diuretics NSAIDS should be avoided in renal disease as they can cause nephrotoxicity Many NSAIDS can be used topically NSAIDS are useful in neuropathic pain 18. Which of the following is excreted in saliva Lithium Chloramphenicol Ampicillin Tetracyclines 19. Rofecoxib was withdrawn due to Gastric ulcer Ischemic heart disease Renal complication liver adenoma 20. What is NOT true for selective COX-2 inhibitor is fewer incidence of gastrointestinal side effect safe in patients with renal insufficiency They donot offer the cardio protective effect The analgesic and anti-inflammtory effects identical to that of non selective NSAID Loading … Question 1 of 20
