NEET MDS UNIT Test – Oral medicine, Biochemistry, pharmacology, general medicine #1

1. Miescher syndrome is associated with

2. Most common cause of Resistant hypertension is

3. Most common cause of nephrotic syndrome in adults:

4. Investigation of choice to diagnose epilepsy

5. Which of the following is not seen in secondary adrenal insufficiency

6. When 2 drugs A and B are compared false statement is

7. The protein rich in basic amino acids, which functions in the packaging of DNA in chromosomes, is

8. Least energy producing cycle

9. Branchial cyst opens most commonly in which area:

10. Urea is produced by the enzyme

11. APC gene is mutated in

12. Glycine is used for synthesis of the following except

13. increased levels of alanine in serum after fasting suggests

14. Multiple supernumerary teeth are most commonly found in

15. Glucose transporters present in the beta cells of the Islet of Langerhans is

16. Drug resistance in Staphylococcus aureus is most commonly acquired by

17. In uncompensated diabetic ketoacidosis

18. Which of these is used as a marker of proliferation ( dysplastic proliferation) in a premalignant lesion:

19. All of the following are sources of acetyl Co-A for fatty acid synthesis except one.Which one is the exception

20. Which one of the following clinical findings excludes the diagnosis of polymyositis

21. antigen associated with cicatricial Pemphigoid

22. which of the following reactions does not convert hydrophobic into hydrophilic groups

23. “shivering” is observed in the early part of postoperative period due to

24. A 29 yrs old woman with a pregnancy of 17 week has a 10 years old boy with down syndrome. She does not want another down syndrome kid; best advice to her is

25. Key enzyme in glycogenolysis

26. Which of the following drugs used for diabetes melitis causes lactic acidosis

27. Which of the following anti-diabetic drugs can be used safely in renal failure

28. different sequence of amino acids having similar structure of proteins is an example of

29. Which of the following drug inhibits cell wall synthesis

30. Tetracycline acts by inhibiting protein synthesis at:

31. TSH, LH, FSH act by

32. Along with INH which vitamin is given

33. The molecule, which is the initiator of cataract formation in the eye lens and whose 1-phosphate derivative is responsible for liver failure is

34. Anaesthetic agent which is explosive in the presence of cautery

35. Inhibition of glycolysis by oxygen is known as

36. The most appropriate drug use for chelation therapy in beta thalassaemia major is

37. A syphilitic gumma is most commonly found on the

38. Fluconazole resistant candidiasis in a HIV positive patient is treated by

39. Tongue shows loss of normal exfoliation of surface epithelium with hypertrophy of filiform papillae in:

40. The direct immunoflourescence pattern seen in pemphigus vulgaris has been described as

41. cell differentiation by surface markers

42. nephrometry is based on the principle of

43. An odour of acetone on the breath can be found in patients with

44. Ground glass appearance, Brown tumors and hypercalcemia are seen

45. The most important parameter to monitor Dengue haemorrhagic fever is

46. Folding of protein chain is due to

47. Safest 1st line ATT in renal failure is

48. Drug of choice in opioid withdrawal:

49. a female patient showing progressive muscle and fat loss on the right side of the face is suffering from

50. Blood transfusion associated acute lung injury occurs due to

51. collagen is rich in

52. Use of aspirin in children with viral disease is associated with

53. antinuclear antibody is found in

54. Cyclooxygenase enzyme is not inhibited by

55. Which of the following antibiotic is used in the treatment of clostridium difficile associated diarrhea

56. Storage form of free energy in the cell is-

57. Which anti tubercular causes reversible Red Orange Urine:

58. Filgrastim is used for treatment of

59. A 60 years old patient having cardiorespiratory arrest in hospital ward, for oxygenation what should be done immediately?

60. Therapeutic drug monitoring is required in all except

61. Streptococci adhere to the oral suraces and contribute to caries development as they

62. Not a characteristic of white infarct:

63. Herpes zoster is caused by

64. Which one of the following intravenous induction agents is the most suitable for day care surgery

65. Blood pressure is difficult to measure in a patient with

66. Which of the following drug is not used for management of acute pulmonary oedema

67. The therapeutic efficacy of antihypertensive drugs is blunted by NSAIDS because they

68. During management of ventricular fibrillation , what is true about use of vasopressin

69. All of the following statements about opioids is correct except

70. All are caused by amino acid deficiency except

71. Which can be given safely in renal failure

72. Creatinine is formed from

73. Which of the following anomaly needs consideration in restorative treatment?

74. Which is the most common manifestation of recurrent HSV1 infection

75. Most common intraoral infection in diabetic patient:

76. Not true of obstructive sleep apnea

77. Cervical cancer caused by:

78. Herpetic koilonychia is herpetic infection of

79. Transport of ADP in and ATP out of mitochondria is inhibited by-

80. Regulating enzymes in gluconeogenesis are all ,except

81. Which of the following is not true about from a transfusion related acute lung injury

82. Which of the following is a precursor of protoporphyrin

83. Major source of ammonia in the kidney is

84. Maximum energy is liberated by hydrolysis of

85. Ocular bobbing is seen in

86. A patient is admitted in casualty with signs of fever, lymphadenopathay etc. Investigations reveal infection by pseudomonas aeruginosa. Drug of choice includes

87. Continuous murmur is seen in all of the following conditions except

88. insulin causes lipogenesis by all except

89. which one of the following does the bisphosphonates primary cause

90. A post operative patient developed septicaemia and was incorrectly started on combination chemotherapy by a new resident doctor. However, when the patient did not respond even after 10 days of antibiotics treatment, the review of the charts was done. It was found that the resident doctor had started the combination of antibiotics which was mutually antagonistic in action. Which one of the following is the most likely combination that was given

91. Highest therapeutic index:

92. In a pregnant woman, which of the following vaccines is not indicated

93. Which of the following antibacterial drug is not used in the treatment of malaria

94. Which of the following acts by inhibiting cell wall synthesis:

95. Decreased basal metabolic rate is seen in:

96. Cardiovascular effects seen in AIDS are all except

97. Treatment of asymptomatic bradycardia is

98. A 10 year old has diffuse bilateral white areas on the buccal mucosa, dorsum of the tongue and the floor of the mouth. The mother tells the dentist that she has noticed this appearance for at least 3 years, but she was not concerned since she has had a similar condition all of her life. The most likely diagnosis is

99. Drug of choice for pseudomembranous enterocolitis

100. during phagocytosis the metabolic process called respiratory burst involves the activation of

101. Acute infection causes:

102. Citrullinemia is due to deficiency of

103. Which of the following is not an intermediate of citric acid cycle

104. A child reports with greenish stains on teeth .The most probable cause is

105. Drug of choice in neonatal seizures

106. Natal and neonatal teeth are not associated with

107. Therapeutic index is a measure of

108. burning tongue will not be associated with which of the following

109. Urinary protein is detected by

110. Virchow’s triad consists of all except:

111. Which is not a monosaccharide

112. Phocomelia is best described as

113. Which of the HPV cause malignancy:

114. which amino acid migrates faster on paper chromatography on methyl cellulose medium

115. Wheel chair sign is seen in

116. Rofecoxib was withdrawn due to

117. Substrate for ATP synthase is-

118. All of the following drugs are used in pituitary adenoma except

119. Eosinophilic granulomas

120. Role of molecular change in ETC is-

121. What is true about Tramadol:

122. The following is not a carrier protein

123. Which of the following is th metabolic pathway in which there is a shuttling of glucose and lactate between muscle and liver during physical exercise

124. If a person is having ventricular tachycardia,extra systoles appears in

125. which one of the following shows dense collagenous stroma with compressive thin strands and cords of epithelium cells

126. What is NOT true for selective COX-2 inhibitor is

127. rheumatoid arthritis, SLE, thyroiditis are examples of

128. Edman’s reagent is

129. To differentiate between hemifacial hypertrophy and unilateral fibrous dysplasia of the maxilla evaluation of which of the following would be most useful

130. a person with von Gierke’s disease has ketosis. All are true for ketosis in this patient except

131. All of the following anticancer agents cause bone marrow depression except

132. Fissured tongue is seen in:

133. which of the following cyst shows maximum amount of recurrence

134. Not essential for brain death

135. which of the following is the major contributor to colloid osmotic pressure

136. Endotoxic shock is initiated by

137. Drug given for emergency treatment of angina in a patient with ischemic heart disease

138. spreading enzyme produced by some species of streptococcus

139. Negative regulator of BMP is

140. Hairy tongue is associated with hypertrophy of:

141. Citrate synthesase is inhibited by

142. True about polio

143. The following is true about malaria

144. Which of the following drugs is used to prevent HIV transmission from HIV positive pregnant mother to child

145. In leprosy, the best bactericidal agent is

146. GNAS1 Gene mutation is associated with

147. A distinctive advantage of tetracycline over penicillin is that tetracyclines

148. Enzyme common between glycogenesis and glycogenolysis

149. All are vasodilators except

150. A patient with severely displaced teeth,fractured enamel ,undefined DEJ and severe attrition may be suffering from

151. The ground substance of the extracellular matrix is made up of

152. A 4-year-old patient comes with her mother for a routine appointment. The mother states that her daughter just started not feeling well and had a mild fever earlier in the day. The daughter has been having trouble swallowing. An intraoral exam reveals multiple 1-mm to 2- mm vesiculopapular lesions of the nasopharynx and soft palate. Your working diagnosis is:

153. Fructose intolerance is to

154. Which of the following metabolic pathway in carbohydrate metabolism is required for synthesis of nucleic acid

155. The conversion of an optically pure isomer (enantiomer) into a mixture of equal amounts of both dextro and levo forms is called as

156. Schwannoma of spinal nerve roots is seen in

157. Earliest marker of renal damage in a known case of diabetes mellitus is:

158. Citrate to cis aconitate conversion is inhibited by

159. Amide group is present in which part of protein

160. Best test for mycoplasma infection is

161. Drug of choice of malignant hyperthermia

162. Which amino acid is not involved in transamination

163. which one of the following shows ‘blueberry lips’

164. Most common cause of Mobius syndrome is use of which of the following drug in pregnancy

165. Syndrome associated with predisposition to development of oral cancer is termed as

166. Grapefruit juice is an

167. In citric acid cycle,NADH is produced by

168. Involucrum is

169. In steady state model of metabolism A->B->C->D, which of the following is true

170. all the statements regarding LDL receptors are true except

171. Consider two patients with atherosclerosis, one is diabetic and other is non-diabetic. When compare to non-diabetic, diabetic patient has hundred times increased risk of

172. Which of the following is true about hypophosphatasia

173. Doppler ultrasound, all are true except?

174. A 40 years old lady reported with history of pain in right cheek since the last 2 months. The pain is sharp, lancinating and sudden in onset and brief in duration. The attacks are triggered by chewing foo She is normal in between the attacks. What is the diagnosis:

175. Bacteriostatic antitubercular drug is

176. 25 years old asthmatic patient on theophyllline is given ciprofloxacin by dentist. He developed dyspnoea and palpitation. What could be the cause

177. which of the following enzymes catalyse the irreversible steps of glycolysis

178. Local anaesthetic used as an antiarrhythmic agent is

179. Which of these is most effective for gluconeogenesis

180. Psammoma bodies are found in

181. the 40nm gap in between the tropocollagen molecule in collagen which serve as the site of bone formation is occupied by which of the following

182. A positive Nikolsky’s sign is a diagnostic feature of

183. What drug competes with bilirubin to bind with albumin:

184. One of the following is not penicillinase susceptible

185. Hockey stick appearance in echocardiography is a feature of

186. Which of these is not a cofactor for glycogen phophorylase, an important enzyme of the glycogenolysis pathway

187. which of the following is present in plasma but absent in serum

188. In which of the following disease maternal antibodies are not protective to the child

189. Co prescription of amoxicillin with clavulanic acid is an example of

190. Golf ball inclusion bodies in RBC are seen in

191. 5HT1 agonists are used as

192. In which type of glycogen storage disease is hyperuricemia a feature

193. Fluid of choice in infant diarrhoea

194. which of the NSAID can be used by parenteral route

195. GLUT-5 is transporter for

196. Mid systolic click is classically heard in

197. A immunocompromised patient came to your clinic with complain of decreased salivary secretion and foul odor from mouth. On histopathological examination ,Acinar necrosis and squamous metaplasia of salivary duct where observed . what is the diagnosis

198. Activity of which of the following enzyme is not affected by insulin

199. An enzyme not involved in glycolysis is

200. The most prominent toxic effects associated with acetaminophen use is

201. calcification of falx cerebri is seen in

202. NADPH is produced by

203. A patient in emergency with symptoms of tachycardia bronchodilation increased temperature and constipation .He may be suffering from poisoning with

204. Hematologic investigations of PT/INR are useful to detect defects in:

205. Which valve is most affected by rheumatic fever

206. Albumin and globulin are classified as

207. Glycogen breakdown leads to formation of

208. The characteristic feature seen during the histogic examination of a langerhans cell histiocytosis lesion is

209. granulomatous gingivitis shows histopathology similar to

210. drug of choice for treatment of infection caused by methicillin resistant staphylococcus aureus is

211. Lactate produced anaerobically is used by

212. In prolonged starvation the main energy source of brain is

213. gluconeogenesis in fasting state is indicated by

214. A nursing staff while putting IV line to a seriously ill patient of HIV accidentally got a needlestick injury. Which of the following investigation will be most appropriate for her

215. APGAR score is a quantitative method of assessing score of new born status based on

216. Which of the following agent causes interstitial nephritis

217. Mechanism of action of chloramphenicol is

218. Reducing equivalents produced in glycolysis are transported from cytosol to mitochondria by

219. Incorrect about Lafora’s disease

220. Which of the following is not a phase 1 reaction in drug metabolism

221. 20% KOH used in the diagnosis of candida albicans. Its mechanism of action is

222. Which of the following is NOT associated with osteogenesis imperfecta?

223. Papillary hyperplasia under a denture is usually due to (an)

224. You have to draw blood from a patient. When will you give EDTA?

225. Patient is suffering from atherosclerosis. Which of the following is the most beneficial drug for prevention of stroke in this patient

226. Amcloblastoma originates from:

227. Loading dose depends upon

228. Hutchison triad includes all of the following except

229. Perioral freckles with risk of breast cancer and intestinal cancer is a feature of:

230. Most important factor for calculating dose of NSAIDS in children

231. Both ketogenic and glucogenic amino acid is

232. Mutation in which chromosome is related to dentinogenesis imperfect

233. Which of the following bone malignancies is most fatal:

234. First sensation to be lost in leprosy

235. Which of the following techniques can be used for exact localisation of a genetic locus

236. Most common structure compressed by aneurysm of posterior communicating artery in the circle of Willis

237. A lady complaints her 9 year old daughter is suffering from oral ulceration, fever and shedding of skin from Palm and soles. She also provided history of premature exfoliation of teeth and increased sweating. She also gave history of using new teething gel available in market for past one month. Her daughter is most probably suffering from

238. Appearance of red macules with, ‘herald sign’ appearing 7-10 days back, 3-4 cm in diameter, shiny ovoid along with skin lumps with silvery sheen is a characteristic of:

239. Cross resistance of isoniazid is seen with

240. Sialologue is an agent used to