NEET MDS UNIT Test – Oral medicine, Biochemistry, pharmacology, general medicine #1

1. Maximum energy is liberated by hydrolysis of

2. Grapefruit juice is an

3. An odour of acetone on the breath can be found in patients with

4. Creatinine is formed from

5. The most appropriate drug use for chelation therapy in beta thalassaemia major is

6. which of the following reactions does not convert hydrophobic into hydrophilic groups

7. Involucrum is

8. Fluconazole resistant candidiasis in a HIV positive patient is treated by

9. True about polio

10. The direct immunoflourescence pattern seen in pemphigus vulgaris has been described as

11. Endotoxic shock is initiated by

12. Most important factor for calculating dose of NSAIDS in children

13. You have to draw blood from a patient. When will you give EDTA?

14. Natal and neonatal teeth are not associated with

15. Multiple supernumerary teeth are most commonly found in

16. Least energy producing cycle

17. Bacteriostatic antitubercular drug is

18. Doppler ultrasound, all are true except?

19. cell differentiation by surface markers

20. Which of the following anti-diabetic drugs can be used safely in renal failure

21. Therapeutic index is a measure of

22. Golf ball inclusion bodies in RBC are seen in

23. dermatotropic viral diseases are

24. APC gene is mutated in

25. 20% KOH used in the diagnosis of candida albicans. Its mechanism of action is

26. Which of the following drugs used for diabetes melitis causes lactic acidosis

27. Co-factor for L-amino acid oxidase is

28. Which of the following antibacterial drug is not used in the treatment of malaria

29. Which one of the following intravenous induction agents is the most suitable for day care surgery

30. TSH, LH, FSH act by

31. Drug of choice in a patient with renal disorder and Vancomycin resistant MRSA:

32. which of the following enzymes catalyse the irreversible steps of glycolysis

33. In steady state model of metabolism A->B->C->D, which of the following is true

34. antinuclear antibody is found in

35. Which of the following is th metabolic pathway in which there is a shuttling of glucose and lactate between muscle and liver during physical exercise

36. A 10 year old has diffuse bilateral white areas on the buccal mucosa, dorsum of the tongue and the floor of the mouth. The mother tells the dentist that she has noticed this appearance for at least 3 years, but she was not concerned since she has had a similar condition all of her life. The most likely diagnosis is

37. Major source of ammonia in the kidney is

38. Eosinophilic granulomas

39. which one of the following does the bisphosphonates primary cause

40. collagen is rich in

41. drug of choice for treatment of infection caused by methicillin resistant staphylococcus aureus is

42. granulomatous gingivitis shows histopathology similar to

43. Which of the HPV cause malignancy:

44. In leprosy, the best bactericidal agent is

45. The molecule, which is the initiator of cataract formation in the eye lens and whose 1-phosphate derivative is responsible for liver failure is

46. Transport of ADP in and ATP out of mitochondria is inhibited by-

47. Fluid of choice in infant diarrhoea

48. Which amino acid is not involved in transamination

49. Safest 1st line ATT in renal failure is

50. Which of the following acts by inhibiting cell wall synthesis:

51. Which of the following metabolic pathway in carbohydrate metabolism is required for synthesis of nucleic acid

52. Most common intraoral infection in diabetic patient:

53. Which is the most common manifestation of recurrent HSV1 infection

54. Which can be given safely in renal failure

55. which of the following is the major contributor to colloid osmotic pressure

56. during phagocytosis the metabolic process called respiratory burst involves the activation of

57. Which of the following drugs is used to prevent HIV transmission from HIV positive pregnant mother to child

58. Hockey stick appearance in echocardiography is a feature of

59. Citrate to cis aconitate conversion is inhibited by

60. Appearance of red macules with, ‘herald sign’ appearing 7-10 days back, 3-4 cm in diameter, shiny ovoid along with skin lumps with silvery sheen is a characteristic of:

61. Mechanism of action of chloramphenicol is

62. Use of aspirin in children with viral disease is associated with

63. nephrometry is based on the principle of

64. Which of the following drug inhibits cell wall synthesis

65. Drug resistance in Staphylococcus aureus is most commonly acquired by

66. Storage form of free energy in the cell is-

67. the 40nm gap in between the tropocollagen molecule in collagen which serve as the site of bone formation is occupied by which of the following

68. Glucose transporters present in the beta cells of the Islet of Langerhans is

69. Anaesthetic agent which is explosive in the presence of cautery

70. burning tongue will not be associated with which of the following

71. Which of the following is not true about from a transfusion related acute lung injury

72. Papillary hyperplasia under a denture is usually due to (an)

73. Not a characteristic of white infarct:

74. Time dependent killing and prolonged post antibiotic effect is seen with

75. Fissured tongue is seen in:

76. Key enzyme in glycogenolysis

77. a female patient showing progressive muscle and fat loss on the right side of the face is suffering from

78. When 2 drugs A and B are compared false statement is

79. which of the following cyst shows maximum amount of recurrence

80. NADPH is produced by

81. which amino acid migrates faster on paper chromatography on methyl cellulose medium

82. The ground substance of the extracellular matrix is made up of

83. increased levels of alanine in serum after fasting suggests

84. which one of the following shows dense collagenous stroma with compressive thin strands and cords of epithelium cells

85. In prolonged starvation the main energy source of brain is

86. Substrate for ATP synthase is-

87. insulin causes lipogenesis by all except

88. Which of the following drug is not used for management of acute pulmonary oedema

89. In a pregnant woman, which of the following vaccines is not indicated

90. If a person is having ventricular tachycardia,extra systoles appears in

91. Local anaesthetic used as an antiarrhythmic agent is

92. Urinary protein is detected by

93. Sialologue is an agent used to

94. Which of the following agent causes interstitial nephritis

95. Which of the following is NOT associated with osteogenesis imperfecta?

96. Hutchison triad includes all of the following except

97. Most common cause of nephrotic syndrome in adults:

98. Rofecoxib was withdrawn due to

99. Which of the following is not a phase 1 reaction in drug metabolism

100. Blood pressure is difficult to measure in a patient with

101. Wheel chair sign is seen in

102. All of the following statements about opioids is correct except

103. Activity of which of the following enzyme is not affected by insulin

104. Therapeutic drug monitoring is required in all except

105. Phocomelia is best described as

106. Ulthoff sign is seen in:

107. Cross resistance of isoniazid is seen with

108. A patient with severely displaced teeth,fractured enamel ,undefined DEJ and severe attrition may be suffering from

109. Loading dose depends upon

110. Negative regulator of BMP is

111. The following is not a carrier protein

112. Which of the following techniques can be used for exact localisation of a genetic locus

113. Best test for mycoplasma infection is

114. Which of the following is true about hypophosphatasia

115. Amcloblastoma originates from:

116. which of the NSAID can be used by parenteral route

117. Glycogen breakdown leads to formation of

118. Folding of protein chain is due to

119. “shivering” is observed in the early part of postoperative period due to

120. The conversion of an optically pure isomer (enantiomer) into a mixture of equal amounts of both dextro and levo forms is called as

121. Perioral freckles with risk of breast cancer and intestinal cancer is a feature of:

122. Tetracycline acts by inhibiting protein synthesis at:

123. APGAR score is a quantitative method of assessing score of new born status based on

124. Xylometazoline is used before nasal intubation as it causes:

125. Which one of the following clinical findings excludes the diagnosis of polymyositis

126. which one of the following shows ‘blueberry lips’

127. In which of the following disease maternal antibodies are not protective to the child

128. Consider two patients with atherosclerosis, one is diabetic and other is non-diabetic. When compare to non-diabetic, diabetic patient has hundred times increased risk of

129. Cardiovascular effects seen in AIDS are all except

130. Drug given for emergency treatment of angina in a patient with ischemic heart disease

131. all the statements regarding LDL receptors are true except

132. Drug of choice of malignant hyperthermia

133. A patient is admitted in casualty with signs of fever, lymphadenopathay etc. Investigations reveal infection by pseudomonas aeruginosa. Drug of choice includes

134. Drug of choice in neonatal seizures

135. Drug of choice for the treatment of peptic ulcer caused due to chronic use of NSAIDs is

136. Which of the following bone malignancies is most fatal:

137. Amide group is present in which part of protein

138. Fructose intolerance is to

139. A 4-year-old patient comes with her mother for a routine appointment. The mother states that her daughter just started not feeling well and had a mild fever earlier in the day. The daughter has been having trouble swallowing. An intraoral exam reveals multiple 1-mm to 2- mm vesiculopapular lesions of the nasopharynx and soft palate. Your working diagnosis is:

140. All of the following are sources of acetyl Co-A for fatty acid synthesis except one.Which one is the exception

141. In uncompensated diabetic ketoacidosis

142. To differentiate between hemifacial hypertrophy and unilateral fibrous dysplasia of the maxilla evaluation of which of the following would be most useful

143. Drug of choice for pseudomembranous enterocolitis

144. Most common structure compressed by aneurysm of posterior communicating artery in the circle of Willis

145. A nursing staff while putting IV line to a seriously ill patient of HIV accidentally got a needlestick injury. Which of the following investigation will be most appropriate for her

146. An enzyme not involved in glycolysis is

147. Which is not a monosaccharide

148. Continuous murmur is seen in all of the following conditions except

149. True regarding dentigerous cyst is all except

150. 5HT1 agonists are used as

151. Glutamine replaced by valine in sickle cell anemia is characterised by

152. 25 years old asthmatic patient on theophyllline is given ciprofloxacin by dentist. He developed dyspnoea and palpitation. What could be the cause

153. Blood transfusion associated acute lung injury occurs due to

154. Citrate synthesase is inhibited by

155. Which of the following is not an intermediate of citric acid cycle

156. Which of the following antibiotic is used in the treatment of clostridium difficile associated diarrhea

157. Cervical cancer caused by:

158. Filgrastim is used for treatment of

159. Proteins are seperated on the basis of charge in

160. Which of these is most effective for gluconeogenesis

161. Regulating enzymes in gluconeogenesis are all ,except

162. Treatment of asymptomatic bradycardia is

163. Which of these is not a cofactor for glycogen phophorylase, an important enzyme of the glycogenolysis pathway

164. Edman’s reagent is

165. Schwannoma of spinal nerve roots is seen in

166. different sequence of amino acids having similar structure of proteins is an example of

167. What drug competes with bilirubin to bind with albumin:

168. All are vasodilators except

169. The therapeutic efficacy of antihypertensive drugs is blunted by NSAIDS because they

170. A 60 years old patient having cardiorespiratory arrest in hospital ward, for oxygenation what should be done immediately?

171. The most important parameter to monitor Dengue haemorrhagic fever is

172. Decreased basal metabolic rate is seen in:

173. A child reports with greenish stains on teeth .The most probable cause is

174. Herpes zoster is caused by

175. All are caused by amino acid deficiency except

176. All of the following drugs are used in pituitary adenoma except

177. Which anti tubercular causes reversible Red Orange Urine:

178. In which type of glycogen storage disease is hyperuricemia a feature

179. First sensation to be lost in leprosy

180. spreading enzyme produced by some species of streptococcus

181. A positive Nikolsky’s sign is a diagnostic feature of

182. Urea is produced by the enzyme

183. rheumatoid arthritis, SLE, thyroiditis are examples of

184. Drug of choice in opioid withdrawal:

185. Co prescription of amoxicillin with clavulanic acid is an example of

186. A syphilitic gumma is most commonly found on the

187. Hairy tongue is associated with hypertrophy of:

188. Glucose 6 phosphatase deficicency is seen in

189. Both ketogenic and glucogenic amino acid is

190. Patient is suffering from atherosclerosis. Which of the following is the most beneficial drug for prevention of stroke in this patient

191. Which of the following is a precursor of protoporphyrin

192. Mutation in which chromosome is related to dentinogenesis imperfect

193. A lady complaints her 9 year old daughter is suffering from oral ulceration, fever and shedding of skin from Palm and soles. She also provided history of premature exfoliation of teeth and increased sweating. She also gave history of using new teething gel available in market for past one month. Her daughter is most probably suffering from

194. The characteristic feature seen during the histogic examination of a langerhans cell histiocytosis lesion is

195. Most common cause of Resistant hypertension is

196. Not essential for brain death

197. Streptococci adhere to the oral suraces and contribute to caries development as they

198. Not true of obstructive sleep apnea

199. a person with von Gierke’s disease has ketosis. All are true for ketosis in this patient except

200. All of the following anticancer agents cause bone marrow depression except

201. Mid systolic click is classically heard in

202. Miescher syndrome is associated with

203. which of the following is present in plasma but absent in serum

204. Role of molecular change in ETC is-

205. antigen associated with cicatricial Pemphigoid

206. Ocular bobbing is seen in

207. The most prominent toxic effects associated with acetaminophen use is

208. Which of the following anomaly needs consideration in restorative treatment?

209. a condition caused by excess of steroid hormone cortisol in the blood level which is caused by pituitary tumor secreting adrenocorticotropic hormone is

210. A 29 yrs old woman with a pregnancy of 17 week has a 10 years old boy with down syndrome. She does not want another down syndrome kid; best advice to her is

211. calcification of falx cerebri is seen in

212. What is NOT true for selective COX-2 inhibitor is

213. One of the following is not penicillinase susceptible

214. gluconeogenesis in fasting state is indicated by

215. GLUT-5 is transporter for

216. Virchow’s triad consists of all except:

217. Reducing equivalents produced in glycolysis are transported from cytosol to mitochondria by

218. Which of the following is an aldose

219. Inhibition of glycolysis by oxygen is known as

220. In oxidative phosphorylation, the ATP production and respiratory chain are linked by-

221. Ground glass appearance, Brown tumors and hypercalcemia are seen

222. Glycine is used for synthesis of the following except

223. In citric acid cycle,NADH is produced by

224. What is true about Tramadol:

225. Herpetic koilonychia is herpetic infection of

226. Acute infection causes:

227. Earliest marker of renal damage in a known case of diabetes mellitus is:

228. A patient in emergency with symptoms of tachycardia bronchodilation increased temperature and constipation .He may be suffering from poisoning with

229. Hematologic investigations of PT/INR are useful to detect defects in:

230. A post operative patient developed septicaemia and was incorrectly started on combination chemotherapy by a new resident doctor. However, when the patient did not respond even after 10 days of antibiotics treatment, the review of the charts was done. It was found that the resident doctor had started the combination of antibiotics which was mutually antagonistic in action. Which one of the following is the most likely combination that was given

231. Citrullinemia is due to deficiency of

232. A 40 years old lady reported with history of pain in right cheek since the last 2 months. The pain is sharp, lancinating and sudden in onset and brief in duration. The attacks are triggered by chewing foo She is normal in between the attacks. What is the diagnosis:

233. Lactate produced anaerobically is used by

234. Incorrect about Lafora’s disease

235. The protein rich in basic amino acids, which functions in the packaging of DNA in chromosomes, is

236. The following is true about malaria

237. A immunocompromised patient came to your clinic with complain of decreased salivary secretion and foul odor from mouth. On histopathological examination ,Acinar necrosis and squamous metaplasia of salivary duct where observed . what is the diagnosis

238. Which of the following is not seen in secondary adrenal insufficiency

239. Which valve is most affected by rheumatic fever

240. Highest therapeutic index: